Improvement of the antioxidant activity, phytochemicals, and cannabinoid compounds of <i>Cannabis sativa</i> by salicylic acid elicitor

Mirzamohammad, Elham; Alirezalu, Abolfazl; Alirezalu, Kazem; Norozi, Asadaolah; Ansari, Afsaneh

doi:10.1002/fsn3.2643

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…In another study, the methanolic extract of the seeds showed an average activity against DPPH with an inhibition value of 75% at 500 µL/mL [ 83 ]. According to these authors, this activity is probably due to the presence of polyphenols and cannabinoids, known for their strong antioxidant capacity [ 164 , 165 ]. Moreover, other seed metabolites, such as lignamides [ 156 ] and proteins [ 157 ], exhibited average antioxidant activities.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities

Hourfane

Mechqoq

Bekkali

et al. 2023

Plants

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For more than a century, Cannabis was considered a narcotic and has been banned by lawmakers all over the world. In recent years, interest in this plant has increased due to its therapeutic potential, in addition to a very interesting chemical composition, characterized by the presence of an atypical family of molecules known as phytocannabinoids. With this emerging interest, it is very important to take stock of what research has been conducted so far on the chemistry and biology of Cannabis sativa. The aim of this review is to describe the traditional uses, chemical composition and biological activities of different parts of this plant, as well as the molecular docking studies. Information was collected from electronic databases, namely SciFinder, ScienceDirect, PubMed and Web of Science. Cannabis is mainly popular for its recreational use, but it is also traditionally used as remedy for the treatment of several diseases, including diabetes, digestive, circulatory, genital, nervous, urinary, skin and respiratory diseases. These biological proprieties are mainly due to the presence of bioactive metabolites represented by more than 550 different molecules. Molecular docking simulations proved the presence of affinities between Cannabis compounds and several enzymes responsible for anti-inflammatory, antidiabetic, antiepileptic and anticancer activities. Several biological activities have been evaluated on the metabolites of Cannabis sativa, and these works have shown the presence of antioxidant, antibacterial, anticoagulant, antifungal, anti-aflatoxigenic, insecticidal, anti-inflammatory, anticancer, neuroprotective and dermocosmetic activities. This paper presents the up-to-date reported investigations and opens many reflections and further research perspectives.

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Section: Resultsmentioning

confidence: 99%

A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities

Hourfane

Mechqoq

Bekkali

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…There is a growing body of evidence that demonstrates that cannabinoids are differentially affected by phytohormone signaling pathways ( Mansouri et al., 2009 ; Mansouri and Asrar, 2012 ; Jalai et al., 2019 ; Mirzamohammad et al., 2021 ; Apicella et al., 2022 ). For example, the exogenous application of SA in one study led to an increase in CBD and THC concentrations but in another led to only an increase in THC production and a decrease in CBD production ( Jalai et al., 2019 ; Mirzamohammad et al., 2021 ). Application of methyl jasmonate (MeJA) to Cannabis plants also led to increased cannabinoid production, specifically THC ( Apicella et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Assessing the adaptive role of cannabidiol (CBD) in Cannabis sativa defense against cannabis aphids

MacWilliams,

Peirce,

Pitt

et al. 2023

Front. Plant Sci.

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Cannabis sativa is known for having unique specialized or secondary metabolites, cannabinoids that are derived from an extension of the terpene pathway in the Cannabis lineage and includes more than 100 other similar metabolites. Despite the assumption that cannabinoids evolved as novel herbivory defense adaptations, there is limited research addressing the role of cannabinoids in C. sativa responses to insect herbivores. Here we investigated the role of cannabidiol (CBD), the predominant cannabinoid in hemp, in plant defense against cannabis aphid (Phorodon cannabis), one of the most damaging pests of hemp. We hypothesize that insect feeding may induce changes in cannabinoids as an adaptive strategy for defense. We found that mean fecundity, net reproductive rate (R0) and adult longevity of cannabis aphids was reduced on the high cannabinoid cultivar compared to the low- cannabinoid cultivar in whole plant assays. In contrast, supplementation of CBD in artificial feeding assays increased aphid fecundity from day 1 to day 3. Additionally, aphid feeding did not impact cannabinoid levels in leaf tissues with the exception of Δ9-tetrahydrocannabinol (THC). This suggests that other cannabinoids and/or metabolites such as terpenes are causing the observed decrease in aphid performance in the whole plant assays. In addition to cannabinoids, C. sativa also possesses a range of defense mechanisms via phytohormone signaling pathways that are well described in other plant species. Indeed, cannabis aphid feeding significantly increased levels of the major phytohormones, salicylic acid, jasmonic acid, and abscisic acid, which are known to be involved in plant defense responses against aphid species. These results highlight the interplay between cannabinoid synthesis and phytohormone pathways and necessitate further investigation into this complex interaction.

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Low UV radiation influenced DNA methylation, gene regulation, cell proliferation, viability, and biochemical differentiation in the cell suspension cultures of Cannabis indica

Abedini,

Iranbakhsh,

Saadatmand

et al. 2024

Journal of Photochemistry and Photobiology B: Biology

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Improvement of the antioxidant activity, phytochemicals, and cannabinoid compounds of Cannabis sativa by salicylic acid elicitor

Cited by 4 publications

References 55 publications

A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities

A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities

Assessing the adaptive role of cannabidiol (CBD) in Cannabis sativa defense against cannabis aphids

Low UV radiation influenced DNA methylation, gene regulation, cell proliferation, viability, and biochemical differentiation in the cell suspension cultures of Cannabis indica

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