Improvement of Th17/Treg balance and Asthma Control Test score by Nigella sativa supplementation in asthmatic children: a new approach to managing asthma

Barlıanto, Wisnu; Wulandari, Desy; Chusniyah, Maya; Kusuma, Hms Chandra; Prawiro, Sumarno Reto

doi:10.25002/tji.2018.686

Cited by 8 publications

(20 citation statements)

References 7 publications

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“…In one study, researchers showed that the oils of N. sativa (15–30 mg/kg) significantly decreased Th17 and also increased Treg percentages. In the same way, Th17/Treg ratio was lower in N. sativa treated group compared to the standard treated group [ 138 ]. Supplementation with N. sativa oil in patients with nonalcoholic fatty liver disease (NAFLD) for 8 weeks decreased the level of FBS, lipid profiles (TG, TC, LDL, and VLDL), liver enzymes (AST and ALT), inflammatory marker (hs-CRP, IL-6, and TNF- α ), whereas it increased the HDL-C levels compared to the placebo (paraffin oil) group [ 139 ].…”

Section: Resultsmentioning

confidence: 99%

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

Moghaddam

Kianmehr

Khazdair

2020

Evidence-Based Complementary and Alternative Medicine

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The use of plants or their isolated bioactive components for the prevention and treatment of various disorders has been developed. Here, we aim to identify effective medicinal plants for relief of cough and respiratory symptoms in children. The data of this review article were obtained from published articles in scientific databases, including PubMed, Google Scholar, and Scopus, until December 2019. The keywords, including “Zataria multiflora Boiss.” OR “Portulaca oleracea L.” OR “Ferula assa-foetida L.” OR “Nigella sativa L.” AND “respiratory symptoms” OR “airway inflammation” OR “smooth muscle relaxant effects,” were searched individually or combined. The mentioned medicinal plants decreased total white blood cell (WBC), neutrophils, and eosinophils counts of blood and lung lavage in animal model-induced respiratory disorders. These plants also have protective effects on serum immunoglobulin, antibody titer, eosinophil count, and proinflammatory cytokines. Evidence from the studies indicated that the abovementioned medicinal plants have smooth muscle relaxant properties (bronchodilator effects) via stimulation of β-adrenoceptor or inhibition of muscarinic receptors (in vitro) and also improved the pulmonary function test in clinical settings. These medicinal plants are safe and easy to use. Based on the anti-inflammatory, anti-antispasmodic, and immunomodulatory effects, the clinical benefit may be assumed, therefore considering a place for these medicinal plants in relieve of chronic cough and symptoms of children’s allergy, asthma, and common cold.

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Section: Resultsmentioning

confidence: 99%

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

Moghaddam

Kianmehr

Khazdair

2020

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, no statement could be made if the change of the intervention group differed significantly from the change in the control group [ 38 ]. Improvements in asthma control as measured via the ACT were reported in three studies using Nigella sativa [ 35 , 39 , 40 ]. Furthermore, an extract of B. serrata gum resin and A. marmelos fruit improved asthma-related quality of life [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Overlap between both domains: Five out of six studies from this herb, herbal mixture, or extract cluster showed significant improvements in both asthma-related as well as immunological parameters, compared to the control group [ 34 , 35 , 36 , 37 , 39 , 40 , 41 ]. Nigella sativa ( N = 3) increased ACT score in children with 1.9 points [ 34 , 35 ], and in adults with 1.3, 1.4 [ 40 ] or 2.1 points [ 39 ]. It also increased PEF variability with 8.2 and 5.8 L/min in adults, depending on the dose used [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…It also increased PEF variability with 8.2 and 5.8 L/min in adults, depending on the dose used [ 40 ]. Nigella sativa also increased IFN-γ with 7.8 pg/mL in children [ 34 , 35 ] and with 0.5 or 0.9 pg/mL in adults [ 40 ]. It decreased IL-4 with 0.3 pg/mL in children [ 34 , 35 ] and eosinophils in blood with 65 cells/µL in adults.…”

Section: Resultsmentioning

confidence: 99%

“…Nigella sativa also increased IFN-γ with 7.8 pg/mL in children [ 34 , 35 ] and with 0.5 or 0.9 pg/mL in adults [ 40 ]. It decreased IL-4 with 0.3 pg/mL in children [ 34 , 35 ] and eosinophils in blood with 65 cells/µL in adults. Saffron ( N = 1) increased FEV 1 with 5% and FVC with 1% and decreased CRP with 37.5 ng/mL in adults [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Interventions to Improve Asthma-Related Outcomes through Immunomodulation: A Systematic Review

2020

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Asthma is a chronic inflammatory disease of the airways, characterized by T-helper (Th) 2 inflammation. Current lifestyle recommendations for asthma patients are to consume a diet high in fruits and vegetables and to maintain a healthy weight. This raises the question of whether other nutritional interventions may also improve asthma-related outcomes and whether these changes occur via immunomodulation. Therefore, we systematically reviewed studies that reported both asthma-related outcomes as well as immunological parameters and searched for relations between these two domains. A systematic search identified 808 studies, of which 28 studies met the inclusion criteria. These studies were divided over six nutritional clusters: herbs, herbal mixtures and extracts (N = 6); supplements (N = 4); weight loss (N = 3); vitamin D3 (N = 5); omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) (N = 5); and whole-food approaches (N = 5). Fifteen studies reported improvements in either asthma-related outcomes or immunological parameters, of which eight studies reported simultaneous improvements in both domains. Two studies reported worsening in either asthma-related outcomes or immunological parameters, of which one study reported a worsening in both domains. Promising interventions used herbs, herbal mixtures or extracts, and omega-3 LCPUFAs, although limited interventions resulted in clinically relevant results. Future studies should focus on further optimizing the beneficial effects of nutritional interventions in asthma patients, e.g., by considering the phenotypes and endotypes of asthma.

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PENGARUH PEMBERIAN Nigella sativa TERHADAP KADAR IGE, IL-6 PLASMA SERTA SKOR ASTHMA CONTROL TEST PADA ANAK ASMA RINGAN DAN SEDANG

Mutaqin

Barlıanto

Santoso

2020

Self Cite

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Asma adalah penyakit saluran respiratori karena inflamasi kronis yang mengakibatkan obstruksi dan hiperreaktivitas saluran respiratori. Patogenesis asma diperankan oleh keseimbangan Th1 dan Th2 yang menstimulasi produksi IgE yang ikatanya dengan sel mast dapat merangsang mediator inflamasi. Selain itu, IL-6 yang diproduksi oleh Th17 juga berperan pada asma. Nigella sativa terbukti dapat menurunkan Th17 dan dapat memperbaiki nilai kontrol asma. Tuuan penelitian ini adalah untuk membuktikan bahwa N. sativa dapat mempengaruhi kadar IgE dan IL-6 plasma serta perbaikan skor Asthma Control Test (ACT) pada anak dengan asma ringan dan sedang. Penelitian ini berjenis eksperimental, clinical trial, pre-post control study. Populasi penelitian yaitu penderita asma ringan dan sedang yang dinilai berdasarkan kriteria GINA 2016. Subjek dibagi menjadi 4 kelompok yaitu kelompok A (asma ringan, mendapat terapi short acting beta agonis, kortikosteroid inhalasi dosis rendah dan N. sativa) dan kelompok B (asma sedang, mendapat terapi long acting beta agonis, kortikosteroid inhalasi dosis rendah dan N. sativa), kelompok C (kontrol) (asma ringan, hanya mendapat terapi short acting beta agonis, kortikosteroid inhalasi dosis rendah) dan kelompok D (asma sedang, hanya mendapat terapi long acting beta agonis, kortikosteroid inhalasi dosis rendah). Pada pasien diuji kadar IgE, IL-6 dan skor ACT sebelum dan sesudah perlakuan yang diberikan perlakuan selama 8 minggu. Data dianalisis secara statistik dengan aplikasi SPSS ver 18. Didapatkan kadar IgE pada kelompok asma sedang (B, D) lebih tinggi dibandingkan dengan asma ringan (A, C) dan didapatkan penurunan rerata kadar IgE total pada semua kelompok meskipun nilainya tidak berbeda bermakna (A: p = 0,482, B: p = 0,277; C: p = 0,18; D: p = 0,655). Didapatkan penurunan rerata kadar IL-6 pada semua kelompok meskipun nilainya tidak berbeda bermakna (A: p = 0,123; B: p = 0,338; C: p = 0,848; D: p = 0,564). Terdapat perbedaan bermakna skor ACT pada kelompok A (p = 0,016) maupun kelompok C (kontrol) (p = 003) dibandingkan dengan sebelum perlakuan. Tidak didapatkan hubungan antara kadar IgE dengan skor ACT maupun IL-6 dengan skor ACT setelah diberikan N. sativa (p > 0,05). N. sativa dapat menurunkan kadar IL-6 dan IgE plasma pada anak dengan asma ringan dan sedang serta perbaikan skor ACT pada anak dengan asma sedang meskipun nilainya tidak berbeda bermakna, tetapi sangat bermakna pada asma ringan. Tidak terdapat hubungan antara penurunan IgE dan IL-6 plasma dengan peningkatan skor ACT setelah pemberian N. sativa pada anak asma ringan dan sedang.

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Improvement of Th17/Treg balance and Asthma Control Test score by Nigella sativa supplementation in asthmatic children: a new approach to managing asthma

Cited by 8 publications

References 7 publications

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

Nutritional Interventions to Improve Asthma-Related Outcomes through Immunomodulation: A Systematic Review

PENGARUH PEMBERIAN Nigella sativa TERHADAP KADAR IGE, IL-6 PLASMA SERTA SKOR ASTHMA CONTROL TEST PADA ANAK ASMA RINGAN DAN SEDANG

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