Improvement of Targeted Therapy by E. coli Phage-lysate Vaccination: Tumor Microenvironment Modulation and Magnetic Nanoparticle Delivery Enhancement in Tumor Tissue
Abstract:BACKGROUND.The tumor microenvironment (TME) has an essential role in cancer development. TME reduces the drug and nanoparticle delivery in tumor tissue and minimizes the treatment outcomes. The new therapeutic strategies of TME reprogramming have shown great promise. One such strategy is TME modulation by the E. coli phage-lysate (EcPHL) vaccination with TME modification and enhancement of magnetic nanoparticles (mNP) uptake by tumor tissue. OBJECTIVES In the current study, we aimed to evaluate the effects of … Show more
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