Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells

Abstract

A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient’s walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report

“…According to Garden (2022), the use of MSCs, applied intravenously in immunomediated cytopenias (immunomediated hemolytic anemia and/or immunomediated thrombocytopenia) showed a positive result in 17 of the 22 dogs followed up. The study showed that, of the 17 patients with a positive response, 12 had a complete response, with or without the help of immunosuppressants, and 5 had clinical and cell number improvement, but with a cell count below normal.…”

“…Immunosuppressive medications are the basis for the treatment of autoimmune diseases, but they can cause adverse effects in the patient. In other autoimmune diseases, such as systemic lupus erythematosus, in which the patient may suffer from several metabolic changes, the use of MSCs may be an option for the treatment of the disease (Ko, et al, 2019).…”

Atualidades Na Saúde E Bem-Estar Animal, Volume 8

“…Os sinais clínicos induzidos pelo LES não são patognomônicos da doença e, são dependentes dos órgãos afetados (ROSADO et al, 2021). Pele, articulações e rins são os órgãos mais acometidos, lesões dermatológicas com hematomas devido à trombocitopenia e hemólise imunomediada, insuficiência renal pela glomerulonefrite (KO et al, 2019) são os achados mais comuns. Entretanto, poliartrite, polimiosite, linfadenopatia, pericardite e pleurite também podem estar presentes (BRKLJACIC et al, 2017).…”

“…Nesse contexto, os principais sinais clínicos e achados laboratoriais que podem ser visualizados em animais com lúpus eritematoso sistêmico são: poliartrite, polimiosite, lesões cutâneas, glomerulonefrite, anemia hemolítica, leucopenia e trombocitopenia (KO et al, 2019). Todos esses sinais clínicos e achados estão intimamente relacionados com as reações de hipersensibilidades dos tipos II, III e IV (TIZARD, 2019).…”