Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants

Yonkov, D; Wetzel, Wolfram; Matthies, H; Roussinov, K

doi:10.1007/bf00426475

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…Previous studies reported that systemically-administered MPD enhances [5] , impairs [6−8] , or has no effect on learning and memory [9−12] . Systemically applied MPD could act throughout the central nervous system and would produce different or even divergent behavioral effects.…”

Section: The Psychostimulant Methylphenidate (Mpd; Also Called Ritalimentioning

confidence: 99%

Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats

Zheng

Liu

Wu³

et al. 2008

SCI CHINA SER C

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The psychostimulant methylphenidate (MPD; also called Ritalin) is a blocker of dopamine and norepinephrine transporter. It has been clinically used for treatment of Attention Deficit and Hyperactivity Disorder (ADHD). There have been inconsistent reports regarding the effects of systemically administered MPD on learning and memory, either in animals or humans. In the present study, we investigated the effect of direct infusion of MPD into the basolateral nucleus of amygdala (BLA) or the anterior cingulate cortex (ACC) on conditioned fear memory. Rats were trained on a one-trial step-through inhibitory avoidance task. MPD was infused bilaterally into the BLA or the ACC, either at '0' or 6 h post-training. Saline was administered as control. Memory retention was tested 48 h post-training. Intra-BLA or intra-ACC infusion of MPD '0' h but not 6 h post-training significantly improved 48-h memory retention: the MPD-treated rats had significant longer step-through latency than controls. The present results indicate that action of MPD in the BLA or the ACC produces a beneficial effect on the consolidation of inhibitory avoidance memory.

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Section: The Psychostimulant Methylphenidate (Mpd; Also Called Ritalimentioning

confidence: 99%

Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats

Zheng

Liu

Wu³

et al. 2008

SCI CHINA SER C

View full text Add to dashboard Cite

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Effect of the memory-improving substance methylglucamine orotate on paradoxical sleep in rats

1984

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The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control days. In the chronic experiment, a sequence of 5 control days, 10 days of MGO treatment, and a further 8 control days was tested. Both acute and chronic administration of MGO resulted in increased paradoxical sleep (PS) latency and a small, but significant, decrease in PS during the first 4 h after injection. This effect seems to be specific to PS, as no effects of MGO on waking or total sleep were found. With chronic administration, no PS rebound occurred within the 8-h recording time during the 8-day post-treatment control period. How the RNA precursor can decrease PS and whether this effect may play a role in the memory-improving action of the substance is discussed in terms of an interrelationship between macromolecular synthesis, sleep, and memory, respectively.

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Memory enhancement: Supra-additive effect of subcutaneous cholinergic drug combinations in mice

Smith²,

1985

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The amnesias characteristic of Alzheimer's disease and other age-related dementias are refractory to conventional pharmacotherapy. A recent treatment strategy is to combine present drugs to improve their memory enhancing effect. We used mice weakly trained on active avoidance in a T-maze to compare the effect of cholinergic drugs, given alone and in two-drug combinations, on retention test performance. All drugs were injected SC immediately after training. Memory retention was tested 1 week later. A dose-response curve was determined for each of four drugs (arecoline, edrophonium, oxotremorine, tacrine) and for each of the six possible two-drug combinations. Each drug and each combination improved retention test performance up to an optimal dose; the improvement decreased with further increases in dose. A striking reduction (66.2%-95.7%) in the optimal dose for enhanced retention was observed with these two-drug combinations.

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Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants

Cited by 8 publications

References 14 publications

Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats

Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats

Effect of the memory-improving substance methylglucamine orotate on paradoxical sleep in rats

Memory enhancement: Supra-additive effect of subcutaneous cholinergic drug combinations in mice

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