Improvement of reproducibility and thermal stability of surface-enhanced Raman scattering-based lateral flow assay strips using silica-encapsulated gold nanoparticles

Jeon, Jin-Hyeok; Lee, See Hi; Joung, Younju; Kim, Kyeongnyeon; Choi, Nak Sam; Choo, Jaebum

doi:10.1016/j.snb.2020.128521

Cited by 44 publications

(36 citation statements)

References 26 publications

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“…The first example of SERS LFIA was performed using a simple spherical Au nanoparticle [ 18 ]. In general, this type of particle seems to be a suitable candidate for the SERS assay because of its easy synthesis and conjugation, and many papers have reported their successful application [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. However, SERS response from Au nanospheres is quite small.…”

Section: Sers Tags For Lfiamentioning

confidence: 99%

“…There are two main types of molecular agents used as Raman reporters for the synthesis of SERS tags for LFIA: dye molecules and thiolated aromatic molecules. The most popular among the dyes is malachite green isothiocyanate (MHITC) [ 19 , 23 , 24 , 36 ]. It is a well-known reporter with quite a large cross-section and numerous Raman peaks in the range of 400–1600 cm −1 .…”

Section: Sers Tags For Lfiamentioning

confidence: 99%

“…To improve the colloidal stability of SERS tags, as a rule, the same approach is used as for traditional LFIA labels, namely, the addition of bovine serum albumin as a secondary stabilizer after conjugation. Another possible approach is to coat the particle with a silica layer [ 21 , 23 , 62 ].…”

Section: Sers Tags For Lfiamentioning

confidence: 99%

“…The calibration curve was constructed from the standard relative Raman intensity ratios (ITL/ICL). The Raman mapping strategy has found widespread use for signal averaging in SERS LFIA [ 19 , 22 , 23 , 30 , 36 , 38 , 45 , 48 , 61 , 62 ]. It should be noted that, in all studies, a strong variation in the Raman signal from point to point within one zone was observed.…”

Section: Sers Signal Accumulation and Data Processingmentioning

confidence: 99%

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Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Khlebtsov

2020

Nanomaterials

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Lateral flow immunoassays (LFIAs) have been developed and used in a wide range of applications, in point-of-care disease diagnoses, environmental safety, and food control. However, in its classical version, it has low sensitivity and can only perform semiquantitative detection, based on colorimetric signals. Over the past decade, surface-enhanced Raman scattering (SERS) tags have been developed in order to decrease the detection limit and enable the quantitative analysis of analytes. Of note, these tags needed new readout systems and signal processing algorithms, while the LFIA design remained unchanged. This review highlights SERS strategies of signal enhancement for LFIAs. The types of labels used, the possible gain in sensitivity from their use, methods of reading and processing the signal, and the prospects for use are discussed.

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Section: Sers Tags For Lfiamentioning

confidence: 99%

Section: Sers Tags For Lfiamentioning

confidence: 99%

Section: Sers Tags For Lfiamentioning

confidence: 99%

Section: Sers Signal Accumulation and Data Processingmentioning

confidence: 99%

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Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Khlebtsov

2020

Nanomaterials

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“…Among paper-based SERS sensors, the advantages are diverse, including cost-effectivity, disposability, autoflow by capillary force, so on. Investigators have improved the plasmonic paper through a number of ways within the very recent days [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids

2020

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Tear glucose is an intriguing biofluid that includes potential biomarkers. While many sensors have emerged nowadays, there is still demand for advanced sensors with nonenzymatic, simple, cost-effective sensing mechanism. Herein, we present a paper-based colorimetric assay by utilizing a gold nanoparticle formation. Experimental characterization substantiated a mechanism in this in situ reduction. Scanning electron microscopy, UV-visible spectrometry, etc. were involved in the scrutiny. As a result, we reached for the rationale whereas the particle formation can be utilized for a glucose sensing using tears. This paper-based detection was insusceptible to physiological tear matrix, i.e., chloride ion effect, false-positive error and synergistic effect by antioxidants. In addition, we evaluated its analytical performance in an artificial tear assay. Of the obtained a linear regressions, the concentration range corresponded to the physiological or pathologic reference range. In addition, within the low-concentration range, a high correlation was resulted 0.965. Furthermore, we investigated statistical validation by employing the Bland–Altman plot. In the end sections of this paper, we denoted its ready-to-use merits by simplicity—as well as the further application of our plasmonic paper.

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Highly Sensitive and Reliable NIR Luminescent Sensing Toward Nitro‐Aromatic Antibiotics in Water

Wang

Shi

Zhang

et al. 2021

Adv Materials Technologies

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Near‐infrared (NIR) light features less photon scatter and deeper penetration, thereby providing a sensitive and reliable platform for qualifying and quantifying trace organic contaminants in water medium. Herein, a lanthanide/β‐diketone complex, Yb(dmh)3(phen) (dmh = 2,6‐dimethyl‐3,5‐heptanedione, phen = 1,10‐phenanthroline), is synthesized and performs characteristic NIR luminescence of Yb3+ ions. The outstanding photophysical properties result from the combination effects of excited‐state inter‐ligand charge transfer, ligand‐to‐metal energy transfer, and high structural symmetry. Noteworthily, this NIR luminophore exhibits state‐of‐the‐art sensitivity toward nitro‐aromatic antibiotics in water. The limits of detection are lower to sub‐nanomolar level for nitroimidazoles (metronidazole 0.18 nM; dimetridazole 0.23 nM; ornidazole 0.28 nM) and even picomolar level for nitrofurans (nitrofurantoin 43 pM; nitrofurazone 46 pM). This exciting sensitivity attributes to photo‐induced electron transfer and inner filter effect between sensor and adsorbed analytes. The sensor is also capable of distinguished stability, selectivity, competitiveness, and anti‐interference, which makes it far better suited to the commercial application. The successfully developed technique of NIR luminescence sensing extends the platform of optical devices and sensing materials, being of practical value in monitoring water quality.

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Improvement of reproducibility and thermal stability of surface-enhanced Raman scattering-based lateral flow assay strips using silica-encapsulated gold nanoparticles

Cited by 44 publications

References 26 publications

Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids

Highly Sensitive and Reliable NIR Luminescent Sensing Toward Nitro‐Aromatic Antibiotics in Water

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