The article deals with the issues of cooperation in the context of increasing sanctions imposed on the Russian Federation transport and logistics complex (TLC).A comprehensive express analysis of the impact of sanctions in different aspects of cooperation has been carried out. The system of anti-crisis measures to reduce the damage from the sanctions imposed on the enterprises of the Russian TLC has been studied.The factors of co-marketing and cooperation in the TLC have been researched as well. The content of the cooperation concept in the TLC has been outlined and the possibility of a targeted and territorial approach stipulated.A sequence of steps for measuring business processes performance and dynamic models of economic development have been worked out. The cooperation framework of TLC enterprises has also been presented. Besides, in order to solve the problems of co-marketing, an algorithm of business process optimization of business entities with respect to different social groups of consumers has been proposed.In the deteriorating economic environment, it is necessary to regulate the system of cooperation in order to increase the TLC customer loyalty. It has been proposed to frame the interaction of TLC business entities on the principle of co-marketing, and to focus on the issue of regional residential community development, both by businesses and by the State.