Improvement of pneumonia by curcumin-loaded bionanosystems based on platycodon grandiflorum polysaccharides via calming cytokine storm

Li, Yang; Guo, Caixia; Chen, Qiang; Su, Yanguo; Guo, Huimin; Liu, Ruoyang; Sun, Changgang; Mi, Shuqi; Wang, Jinqiu; Chen, Daquan

doi:10.1016/j.ijbiomac.2022.01.194

Cited by 29 publications

(11 citation statements)

References 53 publications

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“…Elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are established diagnostic markers of ALI [ 20 , 21 ]. ALI can cause inflammatory storms and even lead to death [ 22 , 23 ]. Although the importance of preventing ALI and liver failure has been recognized for several decades, treatment to relieve symptoms is the most effective approach, as targeted therapies are lacking.…”

Section: Introductionmentioning

confidence: 99%

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway

Wang

et al. 2022

Redox Biology

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Section: Introductionmentioning

confidence: 99%

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway

Wang

et al. 2022

Redox Biology

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“…Based on YIQIHUOXUEJIEDU theory, Li J. X et al (2021) explored the antitumor potential of SANT (astragaloside IV, alpha-solanine, neferine, and 2,3,5,6-tetramethylpyrazine derived from Astragalus mongholicus, Solanum nigrum Linn, Lotus plumule, and Ligusticum, respectively) in heparanase-related triplenegative breast cancer (TNBC) in vitro and in vivo, showed a promising candidate of herbal compounds, and provided novel strategies for using natural compounds to achieve an optimized effect. In addition, the unique TCM treatment features of "same treatment for different diseases" (Hu et al, 2022) and "Meridian induction theory" (Li et al, 2022) have great guiding significance for us to develop new anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Shen

2022

Front. Pharmacol.

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Background: The patent literature contains a large amount of information on the internal state of current industrial technologies that are not available in other literature studies. Scientific articles are the direct achievements of theoretical research in this field and can reveal how current theories in basic research have developed. In this study, the progress and status of natural anticancer products in this field were summarized, and the research hotspots were explored through the analysis of the relevant patent literature and scientific articles.Methods: Patent data were retrieved from the incoPat patent retrieval database, and paper data were retrieved from the Web of Science core set and PubMed. GraphPad Prism 8, Microsoft Excel 2010, and CiteSpace 5.8.R3 were used to perform visual processing. The analyzed patent literature includes the patent applicant type, country (or region), and technical subject. The analyzed scientific article includes academic groups, subject areas, keyword clustering, and burst detection.Results: A total of 20,435 patent families and 38,746 articles were collected by 4 January 2022. At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, Theranekron D6, and gaillardin; 2) topoisomerase inhibitors such as camptothecins, scaffold-hopped flavones, podophyllotoxin, oxocrebanine, and evodiamine derivatives; 3) telomerase inhibitors such as camptothecin and isoquinoline alkaloids of Chelidonium majus, amentoflavone, and emodin; 4) microtubule inhibitors such as kolaflavanone, tanshinone IIA analog, eugenol, and millepachine; 5) immunomodulators such as fucoidan, myricetin, bergapten, and atractylenolide I; 6) tumor microenvironment regulators such as beta-escin and icaritin; 7) multidrug resistance reversal agents such as berberine, quercetin, and dihydromyricetin; and 8) antiangiogenic and antimetastatic agents such as epigallocatechin-3-gallate, lupeol, ononin, and saikosaponin A.Conclusion: Anticancer natural product technology was introduced earlier, but the later development momentum was insufficient. In addition, scientific research activities are relatively closed, and technical exchanges need to be strengthened. Currently, the development of medicinal plants and the research on the anticancer mechanism of natural active products are still research hotspots, especially those related to immune checkpoints, essential oils, and metastatic cancer. Theories of traditional Chinese medicine (TCM), such as “restraining excessiveness to acquire harmony,” “same treatment for different diseases,” “Meridian induction theory,” and “Fuzheng Quxie,” have important guiding significance to the research of anticancer mechanisms and the development of new drugs and can provide new ideas for this process.Systematic Review Registration: [https://sourceforge.net/projects/citespace/], identifier [000755430500001].

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“…COVID-19 induced pneumonia is likely to be associated with hyperinflammation due to severe cytokine storms. − Elevated levels of IL-6, C-reactive protein (CRP), d -dimer, and ferritin are major indications of systemic inflammation and hypoxic respiratory failure among the COVID-19 patients . As per NIH (National Institute of Health, USA), several immunomodulatory and anti-inflammatory agents like Baricitinib, Dexamethasone, Prednisone, Methylprednisolone, and Hydrocortisone have been recommended for the potential treatment approach .…”

Section: Prospects Of Nano-biomed Technology For Mutating Sars-cov-2mentioning

confidence: 99%

Advances in Nanomaterial-Based Platforms to Combat COVID-19: Diagnostics, Preventions, Therapeutics, and Vaccine Developments

Mahmud¹,

Anik

Hossain

et al. 2022

ACS Appl. Bio Mater.

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The COVID-19 pandemic caused by the SARS-CoV-2, a ribonucleic acid (RNA) virus that emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently developed variants of the SARS-CoV-2 virus have been shown to be more potent and expanded at a faster rate. Until now, there is no specific and effective treatment for SARS-CoV-2 in terms of reliable and sustainable recovery. Precaution, prevention, and vaccinations are the only ways to keep the pandemic situation under control. Medical and scientific professionals are now focusing on the repurposing of previous technology and trying to develop more fruitful methodologies to detect the presence of viruses, treat the patients, precautionary items, and vaccine developments. Nanomedicine or nanobased platforms can play a crucial role in these fronts. Researchers are working on many effective approaches by nanosized particles to combat SARS-CoV-2. The role of a nanobased platform to combat SARS-CoV-2 is extremely diverse (i.e., mark to personal protective suit, rapid diagnostic tool to targeted treatment, and vaccine developments). Although there are many theoretical possibilities of a nanobased platform to combat SARS-CoV-2, until now there is an inadequate number of research targeting SARS-CoV-2 to explore such scenarios. This unique mini-review aims to compile and elaborate on the recent advances of nanobased approaches from prevention, diagnostics, treatment to vaccine developments against SARS-CoV-2, and associated challenges.

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Improvement of pneumonia by curcumin-loaded bionanosystems based on platycodon grandiflorum polysaccharides via calming cytokine storm

Cited by 29 publications

References 53 publications

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles

Advances in Nanomaterial-Based Platforms to Combat COVID-19: Diagnostics, Preventions, Therapeutics, and Vaccine Developments

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