Improvement of Pain, Sleep, and Quality of Life in Chronic Pain Patients With Vitamin D Supplementation

Huang, Wei; Shah, Shivani; Long, Qi; Crankshaw, Alicia K.; Tangpricha, Vin

doi:10.1097/ajp.0b013e318255655d

Cited by 120 publications

(118 citation statements)

References 38 publications

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“…By the end of the intervention, the men consuming fatty fish during the study had higher concentrations of vitamin D and n-3 fatty acids (EPA and DHA) than the control group, which may partially mediate the reported differences in sleep quality between the groups. Consistent with previous studies (51,57), vitamin D status was positively correlated with sleep efficiency and sleep quality. Given that SOL and wake time did not change in the fish group but rather worsened in the control group, the conclusion that fatty fish is beneficial for sleep quality is not appropriate.…”

Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingssupporting

confidence: 91%

Effects of Diet on Sleep Quality

St‐Onge

Mikic

Pietrolungo

2016

Advances in Nutrition

387

300

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There is much emerging information surrounding the impact of sleep duration and quality on food choice and consumption in both children and adults. However, less attention has been paid to the effects of dietary patterns and specific foods on nighttime sleep. Early studies have shown that certain dietary patterns may affect not only daytime alertness but also nighttime sleep. In this review, we surveyed the literature to describe the role of food consumption on sleep. Research has focused on the effects of mixed meal patterns, such as high-carbohydrate plus lowfat or low-carbohydrate diets, over the short term on sleep. Such studies highlight a potential effect of macronutrient intakes on sleep variables, particularly alterations in slow wave sleep and rapid eye movement sleep with changes in carbohydrate and fat intakes. Other studies instead examined the intake of specific foods, consumed at a fixed time relative to sleep, on sleep architecture and quality. Those foods, specifically milk, fatty fish, tart cherry juice, and kiwifruit, are reviewed here. Studies provide some evidence for a role of certain dietary patterns and foods in the promotion of high-quality sleep, but more studies are necessary to confirm those preliminary findings. Adv Nutr 2016;7:938-49.

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Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingssupporting

confidence: 91%

Effects of Diet on Sleep Quality

St‐Onge

Mikic

Pietrolungo

2016

Advances in Nutrition

387

300

View full text Add to dashboard Cite

show abstract

“…A study evaluating the effects of cholecalciferol supplementation (1200 IU/ day to individuals with serum 25OHD between 20 and 29 ng/mL and 50,000 IU/weekly to those with serum 25OHD <20 ng/mL) in veterans with multiple areas of chronic pain found a decrease in self-reported pain in both supplemented groups, as well as an improvement in sleep pattern, with decreased sleep latency and increased sleep duration (Huang et al 2013). In another study, patients with nonspecific chronic pain selected from a sleep clinic showed serum 25OHD levels <20 ng/mL (McCarty et al 2013).…”

Section: Future Perspectives: Vitamin D Sleep and Painmentioning

confidence: 99%

The interfaces between vitamin D, sleep and pain

Oliveira

Hirotsu

Tufik

et al. 2017

Journal of Endocrinology

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The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin

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“…[1200 IU daily if serum 25(OH)D levels are insufficient (from 20 to 29 ng/mL) or 50 000 IU weekly if serum 25(OH)D levels are deficient (<20 ng/mL)] improved quality of life, pain and sleep in individuals with chronic pain [12] . The positive effects of vitamin D supplementation on muscle strength, physical performance and quality of life have been attributed to the influence of vitamin D on myocyte and neuron metabolism and function [13][14][15][16] .…”

Section: Huang Et Al Demonstrated That Vitamin D Supplementationmentioning

confidence: 99%

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

et al. 2015

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Aim: To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. Methods: A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium (600 mg/d) alone, calcium (600 mg/d) and cholecalciferol (800 IU/d) or calcium (600 mg/d) and calcitriol (0.25 μg/d), respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, β-CTX and P1NP were measured, and the muscle strength and quality of life were assessed at baseline and at 12-and 24-month follow-ups. Results: Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker P1NP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up. Conclusion: Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

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Improvement of Pain, Sleep, and Quality of Life in Chronic Pain Patients With Vitamin D Supplementation

Cited by 120 publications

References 38 publications

Effects of Diet on Sleep Quality

Effects of Diet on Sleep Quality

The interfaces between vitamin D, sleep and pain

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

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