Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats

Allogeneic and Xenogeneic Transplantation of Adipose-Derived Stem Cells in Immunocompetent Recipients Without Immunosuppressants

“…The first ADSC xenotransplantation study was published in 2003, in which intracerebral transplantation of human ADSCs was found to improve neurological functions in a cerebral ischemic rat model [61]. Interestingly, despite being a xenogeneic transplantation, the investigators observed no evidence of inflammation or rejection.…”

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

“…MSCs can also be isolated from other sources such as adipose tissue, umbilical cord blood and mobilized peripheral blood, and have also been used in transplant studies, [31][32][33][34][35] although yields from the latter two are extremely low. Transplantation of MSCs for CNS repair was first reported in 2000 by Chen et al, 36 after administration of bone marrow with brain-derived neurotrophic factor (BDNF) into a model of middle cerebral artery occlusion (MCAo).…”

Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?

“…Numerous studies have shown neuroprotective effects of human umbilical cord blood stem cells comparable with that of bone marrow stromal cells [1,[28][29][30][31][32][33]. Human adipose tissue is also known to contain pluripotent stromal cells and serves as a well explored alternative to bone marrow and umbilical cells [34][35][36][37][38][39].…”