Improvement of Nasal Bioavailability of Luteinizing Hormone-Releasing Hormone Agonist, Buserelin, by Cyclodextrin Derivatives in Rats

Matsubara, Kazutaka; Abe, Kazuya; Irie, Tetsumi; Uekama, Kaneto

doi:10.1002/jps.2600841108

Cited by 68 publications

(24 citation statements)

References 26 publications

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“…32,33 Cyclodextrins have been reported to enhance the IN delivery of a variety of therapeutic compounds from small molecules to macromolecules. [34][35][36] Because a 1:1 molar ratio is generally assumed for the association of cyclodextrin to a small molecule, the cyclodextrin must be present in excess of the saturating concentration of the small molecule in order to significantly enhance solubility.…”

Section: Resultsmentioning

confidence: 99%

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery

Leonard

Sileno

MacEvilly

et al. 2005

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery

Leonard

Sileno

MacEvilly

et al. 2005

Journal of Pharmaceutical Sciences

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“…Therefore, they have been successfully used for variety of industry, such as solubilizing agents (Shown et al 2010;Szejtli 1998), or in pharmaceutical and environmental remediation (Lu et al 2004;Matsubara et al 1995). However, the effect of HPCD on photocatalytic degradation of PCB3 by TiO 2 was unclear.…”

Section: Degradation Rate Of Pcb3 As Affected By Cosolvents and Surfamentioning

confidence: 98%

TiO2 photocatalytic degradation of 4-chlorobiphenyl as affected by solvents and surfactants

et al. 2012

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Purpose TiO 2 photocatalytic degradation of 4-chlorobiphenyl (PCB3) in aqueous solution under UV irradiation was investigated as affected by different environmental factors, including initial PCB3 concentration, TiO 2 content, UV intensity, H 2 O 2 concentration, cosolvents, and surfactants. Materials and methods The solution of PCB3 with TiO 2 was irradiated by medium mercury lamp. The concentration of PCB3 and intermediates was analyzed by GC-μECD and GC-MS. The values of point charge and bond length were also calculated with ChemOffice 2004 (Mopac unit). Results and discussion Photocatalysis was very effective for PCB3 removal, and the degradation kinetics were fitted with a pseudo-first order reaction model. PCB3 was efficiently degraded in the presence of acetone and acetonitrile, but was completely inhibited with other examined cosolvents. HPCD and Tween80 also inhibited the degradation rate of PCB3, while Brij35 slightly decreased the degradation rate of PCB3 at first, and then increased. The reaction mechanism occurred principally by hydroxyl radicals involving the participation of holes and superoxide anion oxidation.A possible photocatalytic degradation pathway of PCB3 was proposed based on the identified reaction intermediates as well as computer simulation. Conclusions The photocatalytic approach could be successfully applied to degrade PCB3, and cosolvents and surfactants significantly influenced its degradation kinetics.

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“…The chemical derivatization of CDs transforms them into xenobiotics, which may be expected to be more resistant to the intestinal hydrolases than the parent CDs. 62 It should be noted that that the permeation enhancement afforded by the CDs and their epithelial toxicity can not be differentiated from each other. 56 Transmucosal AdministrationssThe practical use of CDs to increase drug solubility and stability and to improve drug delivery from the transmucosal formulations has been extensively reviewed.…”

Section: Pharmacokinetic Profilesmentioning

confidence: 99%

Pharmaceutical Applications of Cyclodextrins. III. Toxicological Issues and Safety Evaluation

Irie

Uekama

1997

Journal of Pharmaceutical Sciences

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835

520

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The objective of this review is to summarize recent findings on the safety profiles of three natural cyclodextrins (alpha-, beta- and gamma-CDs) and several chemically modified CDs. To demonstrate the potential of CDs in pharmaceutical formulations, their stability against non-enzymatic and enzymatic degradations in various body fluids and tissue homogenates and their pharmacokinetics via parenteral, oral, transmucosal, and dermal routes of administration are outlined. Furthermore, the bioadaptabilities of CDs, including in vitro cellular interactions and in vivo safety profiles, via a variety of administration routes are addressed. Finally, the therapeutic potentials of CDs are discussed on the basis of their ability to interact with various endogenous and exogenous lipophiles or, especially for sulfated CDs, their effects on cellular processes mediated by heparin binding growth factors.

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Improvement of Nasal Bioavailability of Luteinizing Hormone-Releasing Hormone Agonist, Buserelin, by Cyclodextrin Derivatives in Rats

Cited by 68 publications

References 26 publications

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery

TiO2 photocatalytic degradation of 4-chlorobiphenyl as affected by solvents and surfactants

Pharmaceutical Applications of Cyclodextrins. III. Toxicological Issues and Safety Evaluation

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