Improvement of mouse embryo development in vitro by prolactin.

Yohkaichiya, Takashi; Fukaya, Takao; Hoshiai, Hiroshi; Yajima, Akira

doi:10.1620/tjem.155.241

Cited by 15 publications

(5 citation statements)

References 16 publications

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“…Majority of oocytes arrest at the single cell stage immediately after fertilization and only 19% of blastocyst-stage embryos can be recovered on day 3.5 of pregnancy in the uterus of PRLRÀ/À animals. The presence of PRLR mRNA during all stages of mouse pre-implantation embryos have been demonstrated (Kiapekou et al, 2005), and PRL has been shown to accelerate preimplantation mouse embryo development in vitro (Yohkaichiya et al, 1988). However, oocyte PRLR does not appear to be essential for the development of the pre-implantation embryo, since embryos from PRLRÀ/À mother that are transplanted into the oviduct of PRLR+/+ foster mothers develop normally.…”

Section: Prl Actions and The Role In Reproductionmentioning

confidence: 99%

Reproductive actions of prolactin mediated through short and long receptor isoforms

Devi

Halperín

2014

Molecular and Cellular Endocrinology

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Section: Prl Actions and The Role In Reproductionmentioning

confidence: 99%

Reproductive actions of prolactin mediated through short and long receptor isoforms

Devi

Halperín

2014

Molecular and Cellular Endocrinology

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“…Divergent effects of PRL on the rate of implantation development of mouse embryos have been reported (Yoshida et al 1987;Yohkaichiya et al 1988;Randall et al 1990). The present studies exclude the absolute requirement for an oocyte PRLR in pre-and postimplantation embryonic development supporting previous investigations Dodds et al 1990) and indicating that the defect must reside in the environment in which the embryo develops.…”

Section: Fertilization and Preimplantation Developmentmentioning

confidence: 99%

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

Ormandy¹,

Camus²,

Barra³

et al. 1997

Genes Dev.

721

429

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Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly reduced mammary gland development after their first, but not subsequent, pregnancies. Homozygous females were sterile owing to a complete failure of embryonic implantation. Moreover, they presented multiple reproductive abnormalities, including irregular cycles, reduced fertilization rates, defective preimplantation embryonic development, and lack of pseudopregnancy. Half of the homozygous males were infertile or showed reduced fertility. This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolactin receptor and its ligands.

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“…The role of PRL in oocyte maturation is controversial. Studies in rabbits, mice, and rats have shown a direct stimulatory effect of PRL in in vitro oocyte maturation and in embryo development 76–79 . Recently, we demonstrated the expression of PRL‐R mRNA in mouse oocytes and preimlantation embryos 80 .…”

Section: The Role Of Hormones and Growth Factors On In Vitro Oocyte Mmentioning

confidence: 84%

“…Studies in rabbits, mice, and rats have shown a direct stimulatory effect of PRL in in vitro oocyte maturation and in embryo development. [76][77][78][79] Recently, we demonstrated the expression of PRL-R mRNA in mouse oocytes and preimlantation embryos. 80 Furthermore, we showed that the addition of PRL to the culture medium during long-term cultures of mouse preantral follicles increases nuclear maturation rate and subsequently fertilization and early embryonic development rates (Kiapekou et al, unpublished data).…”

Section: The Role Of Hormones and Growth Factors On In Vitro Oocyte Mmentioning

confidence: 99%

Oocyte Maturation in Assisted Reproductive Techniques

Loutradis

Kiapekou

Zapanti

et al. 2006

Annals of the New York Academy of Sciences

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Human oocyte maturation is a long process during which nuclear maturation occurs resulting in germinal vesicle breakdown (transition from prophase I to metaphase II) and extrusion of the first polar body. During oocyte maturation, in parallel with nuclear maturation, a number of events take place in the oocyte cytoplasm that assist fertilization and early embryonic development. So far several attempts have been made to mature human oocytes in vitro. The main patient group to which in vitro maturation (IVM) has been applied is polycystic ovarian syndrome. In a concise review we present the techniques used for the IVM of oocytes and the role of hormones and growth factors in IVM and subsequent fertilization and early embryonic development.

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Improvement of mouse embryo development in vitro by prolactin.

Cited by 15 publications

References 16 publications

Reproductive actions of prolactin mediated through short and long receptor isoforms

Reproductive actions of prolactin mediated through short and long receptor isoforms

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

Oocyte Maturation in Assisted Reproductive Techniques

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