Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer’s disease patients

Nakagawa, Toshiyuki; Itoh, Masanori; Ohta, Kazunori; Hayashi, Yuichi; Hayakawa, Miki; Yumura, Yasushi; Akanabe, Hiroshi; Chikaishi, Tokio; Nakagawa, K.; Itoh, Yoshinori; Muro, Takato; Yanagida, Daisuke; Nakabayashi, Ryo; Mori, Tetsuya; Saito, Kazuki; Ohzawa, Kaori; Suzuki, Chihiro; Li, Shimo; Ueda, Masashi; Wang, Miao-xing; Nishida, Emika; Islam, Saiful; Tana,; Kobori, Masuko; Ishii, Takashi

doi:10.1097/wnr.0000000000000594

Cited by 38 publications

(39 citation statements)

References 27 publications

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“…The cardinal hallmarks of AD mainly include amyloid beta senile plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain (Lane, Hardy, & Schott, ). Until now, the exact causal factors of AD remain not completely explored, while existing evidence suggest that dietary elements might be one of the key factors beneficially or adversely affecting AD progression (Dohrmann et al, ; Nakagawa et al, ; Perrone & Grant, ).…”

Section: Introductionmentioning

confidence: 99%

“…Various plant extracts such as apigenin and luteolin have been reported to exhibit possible anti‐AD activity in multiple preclinical and clinical trials (Dey, Bhattacharya, Mukherjee, & Pandey, ). Among these, quercetin (Q) is a flavonoid widely distributed in various plant foods, and has been reported to exhibit neuroprotective effects against AD in both AD patients (Nakagawa et al, ) and different mouse models of AD (Lu, Liu, & Yu, ; Lv et al, ). Meanwhile, recent evidence also reported a synergistic effect of quercetin and α‐lipoic acid in protecting against aluminum chloride‐induced neurotoxicity in rats (Al‐Otaibi, Arafah, Sharma, Alhomida, & Siddiqi, ).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice

et al. 2020

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Dietary advanced glycation end products (dAGEs) might be potential toxins involved in the pathogenesis of Alzheimer’s disease (AD). Quercetin is a flavonoid possessing neuroprotective effects. We aimed to explore whether a 21 days of dAGEs intake would result in cognitive dysfunction in aged ICR mice, and the protective effects of quercetin, with potential mechanisms explored. Fourteen‐month old ICR mice were randomly assigned into four groups, that is, Control, AGEs, quercetin, and AGE diet supplemented with quercetin. Key markers involved in Aβ, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. Gut microbiota and short chain fatty acids profiles from intestinal contents were measured via 16S rRNA gene sequencing and gas chromatography (GC), respectively. Quercetin alleviated cognitive impairment induced by dAGEs in aged mice. This might be associated with that quercetin reduced cathepsin B, tau phosphorylation, and neuroinflammation, and elevated α‐diversity index (ACE, Chao1, and Shannon index), and reduced phylum Verrucomicrobia of gut microbiota. Practical applications Alzheimer’s disease (AD) has been regarded as the commonest cause of progressive dementia for the elderly. This study is the very first to demonstrate that even a short‐term dietary advanced glycation end product (dAGEs) intake induced impaired cognitive function in aged ICR mice, and querectin is capable of reversing dAGEs‐induced cognitive dysfunction. Reduced tau phosphorylation, neuroinflammation, and altered gut microbiota profiles may be involved in querectin’s protective effects against dAGEs‐induced cognitive impairment. Our study suggested that quercetin supplementation might be beneficial for improving cognitive function in elderly subjects with high consumption of dAGEs such as grilling, frying, and broiling of food.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice

et al. 2020

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“…Quercetin (80 and 100 mg/kg, i.p, 21 days) enhanced spatial learning and memory impairment in STZ‐induced AD rats (Ashrafpour, Parsaei, & Sepehri, ). Quercetin improved memory recall in aged C57BL/6J mice that were fed a diet containing 0.5% quercetin for 4 weeks (Nakagawa et al., ). In animal studies involving STZ‐induced diabetic rats, quercetin improved memory impairment.…”

Section: Quercetin and Memorymentioning

confidence: 99%

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei

Mirzababaei

Nassiri‐Asl

2018

Journal of Food Science

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Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer's disease and other types of dementia is necessary.

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“…humans (232). However, other clinical trials failed to report beneficial effects of quercetin on cognitive function (233).…”

Section: Potential Mediators Of Xbp1 Signaling In Neuronsmentioning

confidence: 99%

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

Cissé

Duplan

Checler

2016

Mol Med

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X-box binding protein 1 (XBP1) is a unique basic region leucine zipper transcription factor that was isolated two decades ago in a search for regulators of major histocompatibility complex class II gene expression. XBP1 is a very complex protein that regulates many physiological functions, including the immune system, inflammatory responses and lipid metabolism. Evidence over the past few years suggests that XBP1 also plays an important role in pathological settings, since its activity as a transcription factor has profound effects on the prognosis and progression of diseases such as cancer, neurodegeneration and diabetes. Here we provide an overview of recent advances in our understanding of this multifaceted molecule, particularly in regulating synaptic plasticity and memory function, and the implications in neurodegenerative diseases, with an emphasis on Alzheimer's disease.

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Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer’s disease patients

Cited by 38 publications

References 27 publications

Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice

Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

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