2009
DOI: 10.1254/jphs.08060fp
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Improvement of Memory in Mice and Increase of Hippocampal Excitability in Rats by Ginsenoside Rg1’s Metabolites Ginsenoside Rh1 and Protopanaxatriol

Abstract: Abstract. Ginsenoside Rg1 has been reported to improve cognitive function in many memoryimpaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step through test and electrophysiological approach to investigate the effects of ginsenoside Rg1's primary metabolite ginsenoside Rh1 and end metabolite protopanaxatriol (Ppt) on learning and memory as well as hippocampal excitability. The behavioral study sh… Show more

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Cited by 80 publications
(59 citation statements)
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“…In the Morris water maze test, G-Rh1 (10 mg/kg) markedly decreased the escape latency, and increased the number of crosses and the time spent in the platform, thereby improving the spatial learning ability [59]. Moreover, Wang et al [58] found that the pain threshold was not affected in the tail-flick test, confirming the nootropic effect of G-Rh1. Lee et al [60] compared the effects of seven ginsenosides on neural activity by measuring changes in the slope of fEPSPs.…”
Section: Effect On Nervous Systemsmentioning
confidence: 91%
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“…In the Morris water maze test, G-Rh1 (10 mg/kg) markedly decreased the escape latency, and increased the number of crosses and the time spent in the platform, thereby improving the spatial learning ability [59]. Moreover, Wang et al [58] found that the pain threshold was not affected in the tail-flick test, confirming the nootropic effect of G-Rh1. Lee et al [60] compared the effects of seven ginsenosides on neural activity by measuring changes in the slope of fEPSPs.…”
Section: Effect On Nervous Systemsmentioning
confidence: 91%
“…There was no general conclusion for quality of the whole study. There are six studies that claimed the animals were divided randomly [22,44,50,58,59,70]. However, no study presented any method to generate the allocation sequence.…”
Section: Methodological Quality Of Studiesmentioning
confidence: 99%
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