Improvement of memory function via a combination of exercise and soy peptide supplementation in community-dwelling older adults: A randomized controlled trial

Imaoka, Masakazu; Nakao, Hidetoshi; Nakamura, Misa; Tazaki, Fumie; Hida, M.; Imai, Ryota; Maebuchi, Motohiro; Ibuki, Masahisa; Takeda, Masatoshi

doi:10.1016/j.conctc.2022.100998

Cited by 3 publications

(11 citation statements)

References 44 publications

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“…The included study characteristics are reported in Table 3 . The studies were conducted in United States ( n = 3, [ 47 , 48 , 49 ]), Japan ( n = 3, [ 50 , 51 , 52 ]), Iran ( n = 2, [ 53 , 54 ]), Netherlands ( n = 1, [ 46 ]), China ( n = 1, [ 55 ]), and Brazil ( n = 1, [ 56 ]). In total, there were 806 participants included from studies published between 2002–2022.…”

Section: Resultsmentioning

confidence: 99%

“…The study intervention duration varied between 12 weeks to 1 year. The overall daily dose of protein varied from 0.6 g to 60 g. Most studies provided protein supplementation daily, except for Imaoka et al [ 50 , 51 ] which provided one 4.4 g dose of soy peptide drink once per week. Six studies included an exercise component of either resistance training (RT), aerobic training or both [ 47 , 50 , 51 , 52 , 54 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…The overall daily dose of protein varied from 0.6 g to 60 g. Most studies provided protein supplementation daily, except for Imaoka et al [ 50 , 51 ] which provided one 4.4 g dose of soy peptide drink once per week. Six studies included an exercise component of either resistance training (RT), aerobic training or both [ 47 , 50 , 51 , 52 , 54 , 56 ]. Bijeh et al [ 54 ] was the only study to include a soy only arm, and a soy + RT arm, which could be compared separately to a control (no intervention) and RT only arm, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Bijeh et al [ 54 ] was the only study to include a soy only arm, and a soy + RT arm, which could be compared separately to a control (no intervention) and RT only arm, respectively. Comparisons included animal protein [ 46 , 47 , 48 , 49 , 52 , 54 , 55 , 56 ], no intervention control [ 53 , 55 ], and exercise only controls [ 50 , 51 , 54 , 56 ]. Bakhtiari et al [ 53 ] provided two soy arms (soy nut or textured soy protein) compared to no intervention control, while Beavers et al [ 49 ] was a dedicated weight loss study with both plant-protein and animal-protein (control) interventions in a planned calorie deficit.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Stoodley,

Williams,

Wood

2023

Nutrients

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Maintaining muscle mass, strength, and function is crucial for our aging population. Exercise and dietary protein intake are recommended strategies; however, animal proteins have been the most studied. Plant-based protein sources have lower digestibility and incomplete amino acid profiles. However new innovative plant-based proteins and products may have overcome these issues. Therefore, this systematic review aimed to synthesize the current research and evaluate the effects of plant-based protein interventions compared to placebo on body composition, strength, and physical function in older adults (≥60 years old). The secondary aim was whether exercise improved the effectiveness of plant-based protein on these outcomes. Randomized controlled trials up to January 2023 were identified through Medline, EMBASE, CINAHL, and Cochrane Library databases. Studies contained a plant-protein intervention, and assessed body composition, strength, and/or physical function. Thirteen articles were included, all using soy protein (0.6–60 g daily), from 12 weeks to 1 year. Narrative summary reported positive effects on muscle mass over time, with no significant differences compared to controls (no intervention, exercise only, animal protein, or exercise + animal protein interventions). There was limited impact on strength and function. Meta-analysis showed that plant-protein interventions were comparable to controls, in all outcomes. In conclusion, plant-protein interventions improved muscle mass over time, and were comparable to other interventions, warranting further investigation as an anabolic stimulus in this vulnerable population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Stoodley,

Williams,

Wood

2023

Nutrients

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“…Data that arrived on or before April 10 were included in the analysis. The survey items included GLFS- 25 [ 23 , 24 ], grip strength [ 25 ], walking speed [ 26 ], extremity skeletal muscle mass index [ 27 ], depression [ 28 ], GLFS at the baseline health checkup in 2018 and 2019, general cognitive function [ 29 ], number of medications taken, and basic attributes. The 2020 and 2021 mail-in surveys determined GLFS-25 and assessed depression.…”

Section: Methodsmentioning

confidence: 99%

Association of depressive symptoms with Geriatric Locomotive Function Scale score in community-dwelling older adults living in the state of emergency

et al. 2023

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Background Under the state of emergency, it has been reported that the amount of physical activity among community-dwelling older adults has decreased significantly due to refraining from going out, and there are strong concerns about the Geriatric Locomotive Function Scale and deterioration of mental health. Therefore, this study aimed to investigate whether the depressive state before the coronavirus disease 2019 (COVID-19) pandemic affected the 25-Geriatric Locomotive (GLFS) score during the COVID-19 pandemic among community-dwelling older adults. Methods The participants were 194 community-dwelling older adults (45 men, 149 women) with an average age of 75.5 ± 5.5 years who responded to a self-administered survey conducted three times (preliminary, second, and third) from before the 2018 COVID-19 pandemic to March 2021. Individuals with a score of ≥ 10 on the Geriatric Depression Scale 15 (GDS 15) were excluded. The survey items included the 25-question Geriatric Locomotive Function Scale (GLFS25), GDS 15, and other basic attributes. Those with scores of 5 to 9 on the GDS 15 and those with scores of 0 to 4 were assigned to the depressive symptoms (DS) group and the non-DS group, respectively. Statistical analysis was performed using two-way analysis of variance. The Mann–Whitney U test was used for comparisons between the groups. Results In total, 187 patients were included in the analysis, excluding 7 patients. GLFS 25 showed a significant increase in scores at the second and third time points compared with baseline, and a main effect was confirmed in both groups, with no interaction effect. The second time, the score was 10.0 ± 8.5 and 13.7 ± 10.5 in the non-DS and DS groups, respectively. The third time, the non-DS and DS groups scored 10.8 ± 10.5 and 14.9 ± 10.1 points, respectively, indicating a significant difference. Conclusions Our results revealed that the increase in the GLFS 25 score in community-dwelling older adults during the COVID-19 pandemic was related to their DS during normal times before the pandemic. Evaluating such individuals and providing social support may effectively reduce the deterioration of the GLFS 25 score.

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Effects of Aerobic Interval Training Along with Ginkgo biloba Supplementation on Passive Avoidance Memory and GDNF Gene Expression in Alzheimer Rats

Basirat Dehkordi,

Mogharnasi,

Vahidian-Rezazadeh

et al. 2024

Jundishapur J Nat Pharm Prod

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Background: Alzheimer's disease (AD) represents the most prevalent form of dementia, characterized by memory loss, and is a complex, progressive neurodegenerative condition. Objectives: This study aimed to explore the impact of aerobic interval training (AIT) combined with Ginkgo biloba (GB) supplementation on passive avoidance memory function and the expression of the glial cell-derived neurotrophic factor (GDNF) gene in rats afflicted with AD. Methods: A total of forty-four male Wistar rats, each weighing approximately 250 ± 20 g, were maintained in a controlled environment at a specified temperature. Over 8 weeks (5 days per week), they underwent AIT and received GB supplements at a dosage of 100 mg/kg. The rats were randomly assigned into six groups: healthy control (HC) with 7 rats, AD control (AC) with 8 rats, amyloid-β (Aβ) injection plus GB supplement (Aβ + GB) with 8 rats, Aβ injection plus GB supplement plus AIT (Aβ + GB + AIT) with 8 rats, Aβ injection plus AIT (Aβ + AIT) with 8 rats, and sham surgery (SS) with 5 rats. The shuttlebox apparatus was utilized to assess the effect of Aβ on passive avoidance memory and to confirm disease induction. GDNF gene expression was measured using the qRT-PCR method. Results: The study found significant improvements in passive avoidance memory in the Aβ + AIT and Aβ + GB + AIT groups compared to the AC group after 8 weeks of AIT and GB supplementation (P = 0.02 and P = 0.000, respectively). Long-term memory performance was notably enhanced in the Aβ + GB + AIT group (P = 0.000). Additionally, GDNF expression significantly increased in the Aβ + GB + AIT and Aβ + GB groups in comparison to the AC group (P = 0.000 and P = 0.01, respectively). Conclusions: A synergistic effect of AIT and GB supplementation was observed, leading to an increase in GDNF gene expression and improvements in both passive avoidance memory and long-term memory in male rats with AD.

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Improvement of memory function via a combination of exercise and soy peptide supplementation in community-dwelling older adults: A randomized controlled trial

Cited by 3 publications

References 44 publications

Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Association of depressive symptoms with Geriatric Locomotive Function Scale score in community-dwelling older adults living in the state of emergency

Effects of Aerobic Interval Training Along with Ginkgo biloba Supplementation on Passive Avoidance Memory and GDNF Gene Expression in Alzheimer Rats

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