“…Although the neuropathology of the brain was corrected in only some regions, we were able to achieve correction of hyperactive behaviour and working memory in AAV-TT treated mice over AAV9 treated mice. It is unclear which brain area is responsible for hyperactivity in MPS, however, the frontostriatal pathway has been implicated in ADHD ( Cubillo et al , 2012 ), as it is involved in control of impulsivity, locomotion, affect, attention and emotion ( Takamatsu et al , 2015 ). This pathway connects the cortex, striatum and thalamus ( Morris et al , 2016 ), areas in which we have observed improvement in LAMP2, GFAP and ILB4 levels with AAV-TT treatment.…”