Improvement of Insulin Resistance and Reduction of Cardiovascular Risk Among Obese Patients with Type 2 Diabetes with the Duodenojejunal Bypass Liner

Abstract

The DJBL, when used for a period of 6 months, is effective in the control of diabetes, weight loss, improvement of insulin resistance, and decrease of cardiovascular risk among morbidly obese patients with type 2 diabetes mellitus.

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

“…In particular, the drastic weight loss seen with gastric bypass has resulted in T2DM remission and improvements in IR (fasting insulin, ratio of triglycerides to HDL), β-cell function, and cardiovascular risk factors in adolescents and adults with T2DM. 236,261 In addition, IR (assessed by steady-state plasma glucose) was the sole independent predictor of endothelial dysfunction in adults with T2DM as assessed by flow-mediated dilation, and pioglitazone treatment improved endothelial function, which significantly correlated with improved IR. 262 In summary, mechanisms underlying IR in T1DM and T2DM may differ, and new methods to improve IR in pediatric diabetes mellitus are critically needed.…”

Duodenal–jejunal bypass liners

“…This is demonstrated in a study using the triglyceride to high-density lipoprotein (TG:HDL) ratio as a marker of the metabolic syndrome and insulin resistance [25]. The cohort whose TG:HDL levels were off target at baseline (i.e.…”

Endoscopic Treatment of Metabolic Syndrome

“…Our group in the Gastrointestinal Endoscopy Unit of the University of São Paulo School of Medicine performed a prospective study to evaluates the effectiveness of this method over the control of hyperlipidemia, improvement of insulin resistance, metabolic syndrome, and in the potential benefit in the reduction of cardiovascular risk [34].…”