Improvement of inhaled paraquat induced lung and systemic inflammation, oxidative stress and memory changes by safranal

Beigoli, Sima; Hajizadeh, Ali Asghar; Taghavizadeh Yazdi, Mohammad Ehsan; Khosravi, Reyhaneh; Vafaee, Farzaneh; Boskabady, Mohammad Hossein

doi:10.1016/j.toxicon.2024.107687

Toxicon

2024

DOI: 10.1016/j.toxicon.2024.107687

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Improvement of inhaled paraquat induced lung and systemic inflammation, oxidative stress and memory changes by safranal

Sima Beigoli,

Ali Asghar Hajizadeh,

Mohammad Ehsan Taghavizadeh Yazdi

et al.

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2025

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Cited by 2 publications

References 81 publications

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The preventive effectiveness of Crocus sativus extract in treating lung injuries caused by inhaled paraquat in rats

Memarzia,

Beigoli,

Eshaghi Ghalibaf

et al. 2025

Journal of Ethnopharmacology

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The preventive effectiveness of Crocus sativus extract in treating lung injuries caused by inhaled paraquat in rats

Memarzia,

Beigoli,

Eshaghi Ghalibaf

et al. 2025

Journal of Ethnopharmacology

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Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol

Memarzia,

Amin,

Mokhtari-Zaer

et al. 2024

PPAR Research

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Paraquat (PQ) is an herbicide toxin that induces injury in different organs. The anti‐inflammatory and antioxidant effects of carvacrol were reported previously. The effects of carvacrol and pioglitazone (Pio) alone and their combination on inhaled PQ‐induced systemic and lung oxidative stress and inflammation as well as behavioral changes were examined in rats. In this study, animals were exposed to saline (control [Ctrl]) or PQ (PQ groups) aerosols. PQ‐exposed animals were treated with 0.03 mg/kg/day dexamethasone (Dexa), 20 and 80 mg/kg/day carvacrol (C‐L and C‐H), 5 mg/kg/day Pio, and Pio+C‐L for 16 days. Inhaled PQ markedly enhanced total and differential white blood cell (WBC) counts, nitric oxide (NO), and malondialdehyde (MDA) levels but decreased catalase (CAT) and superoxide dismutase (SOD) activities and thiol levels both in the bronchoalveolar lavage fluid (BALF) and blood and increased interferon‐gamma (INF‐γ) and interleukin‐10 (IL‐10) levels in the BALF (p < 0.001 for all cases) except lymphocyte count in blood which was not significantly changed. The escape latency and traveled distance were increased in the PQ group. However, the time spent in the target quadrant in the Morris water maze (MWM) test and the duration of time latency in the dark room in the shuttle box test were reduced after receiving an electrical shock (p < 0.05–p < 0.001). Inhaled PQ‐induced changes were significantly improved in carvacrol, Pio, Dexa, and especially in the combination of the Pio+C‐L treated groups (p < 0.05–p < 0.001). Carvacrol and Pio improved PQ‐induced changes similar to Dexa, but ameliorative effects produced by combination treatments of Pio+C‐L were more prominent than Pio and C‐L alone, suggesting a potentiating effect for the combination of the two agents.

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Improvement of inhaled paraquat induced lung and systemic inflammation, oxidative stress and memory changes by safranal

Cited by 2 publications

References 81 publications

The preventive effectiveness of Crocus sativus extract in treating lung injuries caused by inhaled paraquat in rats

The preventive effectiveness of Crocus sativus extract in treating lung injuries caused by inhaled paraquat in rats

Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol

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