Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: a review

Guo, Weiling; Mao, Bingyong; Tang, Xin; Zhang, Qiuxiang; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Cui, Shumao

doi:10.1080/10408398.2023.2291188

Cited by 5 publications

(3 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This DNA damage promotes frequent turnover of the colon epithelium and creates favorable conditions for the initiation and progression of cancer. Dietary UDCA supplementation, a natural agonist of TGR5, can significantly reduce the incidence of colon cancer through reducing the inflammatory response of colonic mucosa and damage of oxidative stress to cells ( Guo et al, 2023 ; He et al, 2023 ). Nevertheless, 23-NorDOCA promotes cell proliferation, migration and invasion of hepatocellular carcinoma ( Zuo et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Wang,

Zhu,

Hua

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

IntroductionAlterations in the gut microbiome and bile acid metabolism are known to play a role in the development and progression of colon cancer. Medicinal plants like Astragalus mongholicus Bunge and Curcuma aromatica Salisb. (AC) have shown preferable therapeutic effect on cancer therapy, especially digestive tract tumors like colon cancer. However, the precise mechanisms of AC inhibiting colon cancer, particularly in relation to the gut microbiome and bile acid dynamics, are not fully understood.MethodsOur research aimed to investigate the anti-tumor properties of AC in mice with CT26 colon cancer and further investigate its underlying mechanism via intestinal microbiota. The size and pathological changes of solid tumors in colon cancer are used to evaluate the inhibitory effect of AC on colon cancer. Metagenomics and 16s rRNA gene sequencing were employed to clarify the dysbiosis in the gut microbiome of colon cancer and its impact on colon cancer. The levels of bile acids (BAs) in the feces of mice from each group were measured using UPLC-Qtrap-MS/MS.ResultsAC effectively suppressed the growth of colon cancer and reduced histological damage. Notably, AC treatment led to changes in the gut microbiome composition, with a decrease in pathogenic species like Citrobacter and Candidatus_Arthromitus, and an increase in beneficial microbial populations including Adlercreutzia, Lachnospiraceae_UCG-001, and Parvibacter. Additionally, AC altered bile acid profiles, resulting in a significant decrease in pro-carcinogenic bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA), while increasing the concentration of the cancer-inhibitory bile acid, ursodeoxycholic acid (UDCA). Tracking and analyzing the data, AC may mainly upregulate FabG and baiA genes by increasing the relative abundance of Adlercreutzia and Parvibacter bacteria, which promoting the metabolism of pro-carcinogenic LCA.DiscussionThese findings provide strong evidence supporting the role of AC in regulating gut microbiome-mediated bile acid metabolism, which is crucial in impeding the progression of colon cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Wang,

Zhu,

Hua

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…This DNA damage promotes frequent turnover of the colon epithelium and creates favorable conditions for the initiation and progression of cancer. Dietary UDCA supplementation, a natural agonist of TGR5, can significantly reduce the incidence of colon cancer through reducing the inflammatory response of colonic mucosa and damage of oxidative stress to cells (Guo et al, 2023;He et al, 2023). Nevertheless, 23-NorDOCA promotes cell proliferation, migration and invasion of hepatocellular carcinoma (Zuo et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Image_1.pdf

View full text Add to dashboard Cite

“…This DNA damage promotes frequent turnover of the colon epithelium and creates favorable conditions for the initiation and progression of cancer. Dietary UDCA supplementation, a natural agonist of TGR5, can significantly reduce the incidence of colon cancer through reducing the inflammatory response of colonic mucosa and damage of oxidative stress to cells (Guo et al, 2023;He et al, 2023). Nevertheless, 23-NorDOCA promotes cell proliferation, migration and invasion of hepatocellular carcinoma (Zuo et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Table_2.XLSX

View full text Add to dashboard Cite

Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: a review

Cited by 5 publications

References 188 publications

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Image_1.pdf

Table_2.XLSX

Contact Info

Product

Resources

About