Improvement of in vitro degradation of magnesium oxychloride cement for bone repair by chitosan

Physicochemical properties and in vitro activity of SrHPO4 modified magnesium oxychloride bone cement

“…The compressive strength of human cancellous bone and cortical bone is about 2-45 MPa and 90-230 MPa, and the compressive strength of medical inorganic bone cement used in clinical practice is generally between the two. [28,[43][44][45]. The initial compressive strength of MOC was 112.5 ± 3.9 MPa, but it collapsed after only 12 h of soaking in SBF; while SrHPO 4 -MOC had a gradual decrease in compressive strength after soaking in SBF, the structure was intact and the strength still reached 48.9 ± 2.2 MPa after 28 d (containing 4.0 wt% SrHPO 4 ), and the compressive strength of the specimens was still 8.2 ± 0.9 MPa after 84 d of immersion.…”

“…Magnesium oxychloride cement (MOC) is a kind of MgO-MgCl 2 -H 2 O ternary composite system mixed with active MgO, MgCl 2 and H 2 O [23][24][25]. Compared to the bone cement typically utilized in clinical settings, MOC bone cement has excellent mechanical properties and is biodegradable, and the Mg 2+ produced during degradation can promote the absorption of Ca 2+ in the body, which is beneficial to bone repair [26][27][28]. Therefore, researchers modified MOC to explore its application in bone repair; for example, Wen et al [28] found that the implantation of MOC into animal bodies was able to induce the formation of new bone; Lowther et al [29] compounded silver nitrate with MOC and found that MOC possessed good antibacterial properties and was non-cytotoxic.…”

Magnesium-Containing Silicate Bioceramic Degradable Intramedullary Nail for Bone Fractures

“…When the sintering temperature was increased up to 1225 • C, the bending strength of the BINs decreased, but they still had a high value (~37.5 MPa). This result may be related to the grain size inside the BINs [14,20]. The bending strength of the BINs decreased with the increase in grain size sintered at 1225 • C. Furthermore, the BINs sintered at different temperatures showed similar shrinkage (~76.7%), and there was no significant difference.…”

“…In the past few years, calcium silicate (CSi) ceramics have been extensively studied for use as implants in bone repair due to their excellent osteoconductivity and osteoinductivity [12,13]. However, the fast degradation rate, which cannot match the new bone formation speed [14] and is unfavorable for strength stability, and lower strength limit their further application in bone repair. Magnesium (Mg) is one of the essential elements in the human body and plays an important role in the bone marrow microenvironment.…”

Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

“…The volume ratio of PBS to the surface area of the samples was 10 mL cm −2 . 32 The degradation process was carried out in a constant temperature oscillation incubator at 37 °C and 80 rpm. Three parallel samples were used for each treatment group.…”