Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel

Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit

“…A 5% or 10% (v/v) hydrogel of Sanchi extract was prepared. Hyaluronic acid/gelatin (HA/G) hydrogels were designed as previously described [ 16 , 17 ]. A 15% aqueous gelatin solution was prepared using deionized water and gelatin.…”

Renal tissue engineering for regenerative medicine using polymers and hydrogels

“…Injected mice were seen to have a normal appearance of the kidney with a decreased expression of pro-inflammatory and pro-fibrotic components, increased expression of anti-inflammatory genes, and much reduced IgA deposition. 126 In another study, murine pluripotent embryonic stem cells were packed into a gelatin microcryogel as a cell carrier to regenerate kidneys damaged using the 5/6 nephrectomy model of chronic kidney diseases. The cell-hydrogel was wrapped with the incised kidney by the omental flap.…”

“…In most cases, ECM derived from the kidney or Matrigel 91,92,96 have been extensively utilised. Using other bioactive components such as hyaluronic acid 116,126,144 and fibrin 40,131,132 has also created a better renal cell growth environment. Hence, work carried out shows that renal tissue engineering is feasible in generating a cellularly functional kidney tissue that can perform the intended function within the human body.…”

Concentration Selection of Biofriendly Enzyme-Modified Gelatin Hydrogels for Periodontal Bone Regeneration

“…Gelatin has good biocompatibility, and it was reported that gelatin concentration could affect the characterization and hemocompatibility of the polyvinyl alcohol–gelatin hydrogel . Besides, it was also mentioned that the stiffness of the hydrogel could also be significantly modulated by altering the concentrations and ratios of gelatin-based hydrogel . However, pure gelatin hydrogel has thermal reversibility, which leads to difficulty in carrying out subsequent experiments.…”

“…13 Besides, it was also mentioned that the stiffness of the hydrogel could also be significantly modulated by altering the concentrations and ratios of gelatin-based hydrogel. 14 However, pure gelatin hydrogel has thermal reversibility, which leads to difficulty in carrying out subsequent experiments. Thus, previous studies have reported the application of various cross-linkers and photoinitiators, which might have potential cytotoxicity.…”