Improvement of ginsenoside Rg1 on hematopoietic function in cyclophosphamide-induced myelosuppression mice

Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice

“…On the contrary, ECH had no effect on the proliferation of BMSCs from 5-FU treated mice. To exclude the possibility that the negative effect was not due to the cell growth condition, in the experimental setting, we also included Rg1, a herb component which has been proven to stimulate BMSCs from myelosuppression mice growth, as a positive control [33].…”

“…Traditional Chinese medicine is an available option which gains in popularity [5]. In the past several years, many studies focused on the effects of Chinese herbal medications to prevent and treat chemotherapy related myelosuppression [33,35].…”

Ginseng-Derived Panaxadiol Saponins Promote Hematopoiesis Recovery in Cyclophosphamide-Induced Myelosuppressive Mice: Potential Novel Treatment of Chemotherapy-Induced Cytopenias

“…SCXK (Hu) 2013-0016. The murine model with chemotherapyinduced myelosuppression was established, (17) a dose of 100 mg/kg of CTX was injected intraperitoneally for 3 days; the peripheral blood white blood cells (WBC), neutrophil (NEU) and platelet (PLT) counts were detected.…”

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

“…Similarly, ginsenoside Rb1 reduces CP‐induced genotoxicity and cytotoxicity to normal cells by increasing superoxide dismutase and glutathione peroxidase activities and inhibits the increased level of malondialdehyde caused by CP without reducing CP antitumor activity (Zhang et al, ). On the other hand, bone marrow suppression is usually observed during CP treatment; however, ginsenoside Rg1 has the ability to recover hematopoietic system function (Xu et al, ).…”