Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial

Corley, Douglas A.; Katz, Philip O.; Wo, John M.; Stefan, Andreas; Patti, Marco G.; Rothstein, Richard I.; Edmundowicz, Steven A.; Kline, Michael M.; Mason, Rodney J.; Wolfe, M. Michael

doi:10.1016/s0016-5085(03)01052-7

Cited by 302 publications

(202 citation statements)

References 37 publications

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“…The symptom score related to heartburn improved initially in most patients and this improvement persisted. A total of 34% of patients were back on PPIs and an additional 38% were regularly taking antacids at 1 yr. A sham treatment controlled trial has also recently been completed (132). Heartburn quality of life, median heartburn score, and SF 36 physical quality of life were improved more with active treatment compared to sham therapy.…”

Section: Level Of Evidence: IIImentioning

confidence: 99%

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

DeVault

Castell

2005

Am J Gastroenterology

798

493

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Section: Level Of Evidence: IIImentioning

confidence: 99%

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

DeVault

Castell

2005

Am J Gastroenterology

798

493

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“…At 6 months, patients in the treatment group experienced improved heartburn scores (61 vs 33%; p = 0.05) and quality of life scores (61 vs 30%). At 12-months follow-up, symptomatic improvement was maintained in the treatment group [12].…”

Section: Editorialmentioning

confidence: 85%

Comparing the effectiveness of endoscopic full-thickness plication and endoscopic radiofrequency treatments for patients with GERD

Parker

Smith

2010

Expert Review of Gastroenterology & Hepatology

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“…Post-hoc analysis showed that responders had a significant decrease in distal esophageal acid exposure compared to non-responders. Corley et al [4] reported the first sham study demonstrating significant improvement of reflux symptoms and quality of life. However, neither PPI use nor acid exposure were affected significantly by experimental treatment.…”

Section: Radiofrequency Energymentioning

confidence: 99%

Treatment of Gastroesophageal Reflux Disease: Endoscopic Aspects

Špičák

2007

Dig Dis

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Gastroesophageal reflux disease (GERD) is a very common chronic disorder manifesting itself as heartburn, regurgitation, or dysphagia, possibly leading to esophagitis, Barrett’s esophagus and adenocarcinoma, and has a major impact on the patient’s quality of life. Both medical treatment and surgery are well-established methods with several limitations. Recently, three types of endoscopic methods in several modifications have been developed: (1) Radiofrequency therapy (Stretta procedure) is available both in Europe and USA and more than 5,000 patients have been treated to date. (2) Injection therapy requires the injection of bulking agents or implantation of bioprosthesis into the lower esophageal sphincter (LES) zone. Both Enteryx was withdrawn from the market in 2005, and Gatekeeper was suspended before FDA approval. (3) Suturing/plication therapy is based on the plication at the level of the LES, and most of all techniques resemble the principle of surgical treatment. Despite sophisticated technologies and promising short-term results, all these techniques are associated with inconsistencies, controversies, and relevant adverse affects. According to current practice, use of endoscopic methods is justifiable only as part of clinical trials. Many aspects, including commercial ones, will influence future developments in this area, which are difficult to predict.

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Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial

Cited by 302 publications

References 37 publications

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

Comparing the effectiveness of endoscopic full-thickness plication and endoscopic radiofrequency treatments for patients with GERD

Treatment of Gastroesophageal Reflux Disease: Endoscopic Aspects

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