Improvement of functional capacity in sacubitril-valsartan treated patients assessed by cardiopulmonary exercise test

Malfatto, Gabriella; Ravaro, S.; Caravita, Sergio; Baratto, Claudia; Sorropago, Antonio; Giglio, A.; Tomaselli, Michele; Parati, Gianfranco; Villani, Alessandra

doi:10.1080/00015385.2019.1669317

Cited by 19 publications

(18 citation statements)

References 20 publications

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“…In the past 2 years, sacubitril/valsartan has been proven to be superior to ACEI/ARB in improving cardiac outcomes and reversing ventricular remodeling (Hajra et al, 2019). Besides, sacubitril/valsartan could improve exercise tolerance (Malfatto et al, 2020;Piepoli et al, 2021), showing promising applications in the treatment of AMI and reducing all-cause deaths. The TCM theory considers that blood stasis syndrome, phlegm-dampness syndrome, Qi-deficiency syndrome, Yang-deficiency syndrome, deficiency in origin, and excess in superficiality or deficiencyexcess mixing occur following AMI.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Intervenes Ventricular Remodeling Following Acute Myocardial Infarction: Evidence From 40 Random Controlled Trials With 3,659 Subjects

Zhang

Liang

2021

Front. Pharmacol.

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Objectives: We intend to conduct a meta-analysis on the systematic evaluation of traditional Chinese medicine (TCM) in the treatment of ventricular remodeling following acute myocardial infarction (AMI). Our findings may provide certain references for the clinical treatment of ventricular remodeling.Methods: A systematic literature search was conducted in PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang Data, CQVIP, and CBM before 20 July 2020. Data were analyzed using a random/fixed-effect model. Primary outcomes included the effectiveness and TCM syndrome score (TCMSS). Secondary outcomes included 1) echocardiography data, including the left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume index (LVEDVi), left ventricular end-systolic volume index (LVESVi), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular ejection fraction (LVEF), E/A, stroke volume (SV), and wall motion score (WMS); 2) serum indicators, including the B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP), and C-reactive protein (CRP) or high sensitivity CRP (hs-CRP); (3) major adverse cardiovascular events (MACE) and other adverse eventsResults: Forty RCTs involving 3,659 subjects were recruited. Our findings proved that a combination of TCM or TCM preparations with conventional Western medicine for preventing and reversing ventricular remodeling at post-AMI could remarkably enhance the total effectiveness and reduced TCMSS. Moreover, myocardial functions (LVEF, E/A, and SV), ventricular remodeling (LVEDVi, LVESVi, LVEDV, LVESV, LVEDD, LVESD, LVPWT, and WMS), serum levels of BNP and CRP, and MACE were significantly improved by the combination of TCM or TCM preparations with conventional Western medicine. Nevertheless, IVST and the incidence of other adverse events were comparable between control and experimental groupsConclusion: The combination of TCM or TCM preparations and conventional Western medicine can alleviate the process of ventricular remodeling, enhance cardiac function, and reduce the incidence of MACE in AMI patients.

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Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Intervenes Ventricular Remodeling Following Acute Myocardial Infarction: Evidence From 40 Random Controlled Trials With 3,659 Subjects

Zhang

Liang

2021

Front. Pharmacol.

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“…A relevant question is whether these improvements had to be ascribed to the exercise training alone or whether other components of the rehabilitation intervention also concurred to the observed benefits. Theoretically, according to literature data showing an improvement in functional capacity and cardiopulmonary parameters in patients with HF (Giallauria et al, 2020;Malfatto et al, 2020;Dos Santos et al, 2021), we cannot dismiss the possibility that the optimization of pharmacological treatment might also have played a role. However, we have to underscore that, in our study, changes in therapy concerned a very limited number of patients over a limited number of days.…”

Section: Discussionmentioning

confidence: 94%

The Impact of Cardiac Rehabilitation on Activities of Daily Life in Elderly Patients With Heart Failure

et al. 2022

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Background: In elderly chronic heart failure (HF) patients, activities of daily living (ADLs) require the use of a high proportion of patients’ peak aerobic capacity, heart rate, and ventilation.Objectives: To assess the effects of short-term comprehensive cardiac rehabilitation (CR) on the metabolic requirement of ADLs in elderly patients with chronic HF.Methods: The study population comprised 99 elderly chronic HF patients (mean age 72 ± 5 years, 80% male, 61% ejection fraction <40%, mean NT-proBNP 2,559 ± 4,511 pg/ml) participating in a short-term (mean days 19 ± 7) residential CR program. Before and after CR, participants, while wearing a portable ergospirometer, performed a standardized ADL battery: ADL1 (getting dressed), ADL2 (folding 8 towels), ADL3 (putting away 6 bottles), ADL4 (making a bed), ADL5 (sweeping the floor for 4 min), ADL6 (climbing 1 flight of stairs carrying a 1.5 Kg load), and ADL7 (a standard 6-min walking test).Results: After CR, task-related oxygen uptake did not change in any of the domestic ADLs. Notably, there was a significant decrease in the cumulative time required to perform ADLs (ADL 1–4 and ADL6; from 412 ± 147 to 388 ± 141 s, p = 0.001) and a reduction in maximal heart rate in ADL1 and 3 (p = 0.005 and p = 0.027, respectively). Changes occurred in the 6MWT with an increase in oxygen uptake (p = 0.005) and in the distance covered (p < 0.001) and a significant decrease in the Borg scale of dyspnea (p = 0.004).Conclusion: Elderly patients with chronic heart failure who are engaged in a short-term residential CR program improve the performance of routine ADLs.

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“…Although PARAGON-HF reported no mortality benefit in HFpEF, it leads to a modest improvement in the New York Heart Association (NYHA) class [9]. In addition, many studies have reported a better cardiovascular outcome with sacubitril/valsartan, but its effect on depression and anxiety levels is not yet known [10,11].…”

Section: Introductionmentioning

confidence: 99%

Outcome of angiotensin receptor-neprilysin inhibitor on anxiety and depression in heart failure with reduced ejection fraction vs. heart failure with preserved ejection fraction

Malik

Shahid

Shah

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

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Improvement of functional capacity in sacubitril-valsartan treated patients assessed by cardiopulmonary exercise test

Cited by 19 publications

References 20 publications

Traditional Chinese Medicine Intervenes Ventricular Remodeling Following Acute Myocardial Infarction: Evidence From 40 Random Controlled Trials With 3,659 Subjects

Traditional Chinese Medicine Intervenes Ventricular Remodeling Following Acute Myocardial Infarction: Evidence From 40 Random Controlled Trials With 3,659 Subjects

The Impact of Cardiac Rehabilitation on Activities of Daily Life in Elderly Patients With Heart Failure

Outcome of angiotensin receptor-neprilysin inhibitor on anxiety and depression in heart failure with reduced ejection fraction vs. heart failure with preserved ejection fraction

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