Improvement of Fatigue and Quality of Life in Patients with Quiescent Inflammatory Bowel Disease Following a Personalized Exercise Program

Erp, Liselot W van; Roosenboom, Britt; Komdeur, Prashant; Dijkstra-Heida, W.; Wisse, Jolien; Horje, Carmen S. Horjus Talabur; Liem, Camilo S; Cingel, R. E. H. van; Wahab, Peter J.; Groenen, Marcel

doi:10.1007/s10620-020-06222-5

Cited by 23 publications

(47 citation statements)

References 31 publications

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“…As stated before, in previous studies patients were supervised while exercising. 12,13,19 Social support and increased exchange with other affected people and medical staff could be a cause for the significant increase in scores for general wellbeing not observed by us. 36 Our study has several strengths.…”

Section: Discussionmentioning

confidence: 60%

“…[1][2][3][4] Earlier studies have shown an increase in general wellbeing through physical activity. 12,13,19 We could observe a significant difference only in the subclass emotional function in the endurance group. As stated before, in previous studies patients were supervised while exercising.…”

Section: Discussionmentioning

confidence: 61%

“…We therefore assume that both types of exercise could cause beneficial effects on other comorbidities of CD patients such as osteopenia and osteoporosis, because muscle strength serves as a predictor of bone mineral density in CD. 35 In addition, an increase in strength ameliorates fatigue, as recently shown by van Erp et al 19 Positive effects on other comorbidities such as fatigue, depression and the immune system have also been reported in other diseases such as cancer, mood disorders or cardiovascular diseases. [1][2][3][4] Earlier studies have shown an increase in general wellbeing through physical activity.…”

Section: Discussionmentioning

confidence: 84%

“…These findings are consistent with previous investigations with other types of exercise programmes. [12][13][14][15][17][18][19] Both moderate endurance training and moderate muscle training can therefore be categorised as safe modalities and recommended to patients according to their personal preferences and needs.…”

Section: Discussionmentioning

confidence: 99%

“…16 So far, there have been only three studies investigating the effects of muscle training in CD patients. [17][18][19] Only one investigation included a control group, however, not assessing effects on disease activity, wellbeing and strength. 18 The majority of these previous studies focused on supervised exercise programmes which took place in research facilities or fitness centres.…”

Section: Introductionmentioning

confidence: 99%

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Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn’s disease

et al. 2020

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Background and aims Physical activity is beneficial in several chronic disorders including Crohn′s disease, but the preferred type of exercise is unknown. Our study aimed to examine and compare the safety, feasibility and potential beneficial effects of individual moderate endurance and moderate muscle training in patients with Crohn’s disease. Methods Quiescent or mildly active (Crohn’s disease activity index <220) patients with Crohn’s disease were randomly allocated to either a control, endurance, or muscle training group. Participants exercised individually for 3 months three times per week. Endpoints included dropout rate, disease activity, inflammatory parameters including faecal calprotectin, anthropometric data, quality of life, physical activity and strength. Results A total of 45 patients with Crohn’s disease were randomly allocated. In the endurance group ( n = 17), the dropout rate was significantly higher (47% vs. 13%) compared with the muscle group ( n = 15). In both groups the maximal and average strength in the upper and lower extremities increased significantly (all P < 0.04). In the endurance group emotional function was significantly improved ( P = 0.03). Statistically significant changes of disease activity and other outcome parameters were not observed in this pilot cohort. Conclusion Both individual moderate endurance and muscle training can be safely performed in patients with mild or quiescent Crohn’s disease. Muscle training appears more feasible and may be favoured. Both forms of exercise have beneficial effects on strength. Quality of life increased in both intervention groups, although statistical significance was only reached in one subgroup.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn’s disease

et al. 2020

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Fatigue is associated with disease severity in adult patients with hidradenitis suppurativa

Chodziuk,

Holgersen,

Nielsen

et al. 2024

JEADV Clinical Practice

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Background: Patients with hidradenitis suppurativa (HS) experience fatigue, but no studies have yet examined the association between HS severity and fatigue intensity. Objectives:To examine the possible association between HS severity and fatigue and identify fatigue subtypes present in patients with HS.Methods: Adult patients with HS participated in a survey assessing fatigue using the Multidimensional Fatigue Inventory-20. Disease severity was determined by self-report.Results: Data from 654 adult patients with HS were analysed and compared with 3,788 reference individuals from the general population. Total and subtype fatigue scores for patients with HS were significantly higher compared with the general population reference individuals and increased with higher HS severity, itch, pain, sleep, dermatology life quality index scores and lower socioeconomic status.The association between HS severity and increased fatigue scores remained statistically significant after adjustment for age, sex, and socioeconomic status.Conclusions: Patients with HS had a significantly higher fatigue score compared with the general population reference individuals in a severity-dependent manner.

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A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease

Gettigan

Allen

Sedaghat

et al. 2023

Int J Colorectal Dis

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Purpose Given the substantial risk of treatment failure in inflammatory bowel disease (IBD), adjuvant therapies may play a role in disease management. We aim to carry out a systematic review to examine the effects of structured exercise on the inflammatory response in patients with IBD. Our secondary aim is to examine the effect of structured exercise programmes on body composition given both an increase in visceral obesity and the presence of sarcopenia have deleterious effects on outcomes in IBD. Methods A systematic review was carried out following the Methodological Expectations of Cochrane Intervention Reviews (MECIR) manual and the Cochrane Handbook for Systematic Reviews of Interventions. Title/Abstract and MeSH Terms were used to search for relevant studies. Results In total, 1516 records were screened for eligibility, and 148 records were reviewed for eligibility, of which 16 were included and a further 7 studies were identified from hand searching references. Four studies included body composition outcomes, and 14 studies reviewed the inflammatory response to exercise. Conclusion Further studies of adequate duration are required to include patients with more active disease to demonstrate an inflammatory response to exercise. Body composition measurements including muscle mass and visceral adiposity may play a key role in response to medical therapy in IBD and should be included as exploratory outcomes in future studies. A meta-analysis was not carried out due to the significant heterogeneity amongst studies.

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Improvement of Fatigue and Quality of Life in Patients with Quiescent Inflammatory Bowel Disease Following a Personalized Exercise Program

Cited by 23 publications

References 31 publications

Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn’s disease

Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn’s disease

Fatigue is associated with disease severity in adult patients with hidradenitis suppurativa

A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease

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