Improvement of Diagnostic Accuracy of Transvaginal Ultrasound for Identification of Endometrial Malignancies by Using Cutoff Level of Endometrial Thickness Based on Length of Time Since Menopause

Tsuda, Hiroshi; Kawabata, Masami; Kawabata, Kazume; Yamamoto, Kumio; Umesaki, Naohiko

doi:10.1006/gyno.1996.4461

Cited by 30 publications

(24 citation statements)

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“…We also found that the endometrium significantly increased in thickness until the age of 41-50 years and then decreased. Some authors have reported that endometrial thickness decreases with age [21][22][23], which is in accordance with our results as far as the oldest age group is concerned. We observed a peak in endometrial thickness of 1.4 cm in the 41-50-year-old group, which then decreased to 1.2 cm for the 51-80 year olds.…”

Section: Discussionsupporting

confidence: 93%

MR imaging of the uterus and cervix in healthy women: Determination of normal values

et al. 2006

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The purpose of this study was to establish normal values for the volume of the uterus and cervix in MRI based on age and the menstrual cycle phase. We performed MRI of the pelvis in 100 healthy women. For the uterus, they were further divided into two groups: one with myomas and/or adenomyosis and one without either. The volume of the uterus and cervix and thickness of the uterine wall layers were analysed by age and the menstrual cycle phase. The mean volume of the uterus in both groups and the cervix significantly increased with age to reach its peak at 41-50 years, and then dropped. Likewise, the thickness of the endometrium and the junctional zone, but not the myometrium, significantly increased until 41-50 years, and then decreased. When we compared the volume of the uterus and cervix and the thickness of the uterine wall layers between the two phases of the menstrual cycle, we found no significant differences. The volume of the uterus and cervix and the thickness of the endometrium and junctional zone differ significantly with age, but not between the two phases of the menstrual cycle. Knowledge of MRI-related normal values can be expected to aid the early identification of uterine pathologies.

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Section: Discussionsupporting

confidence: 93%

MR imaging of the uterus and cervix in healthy women: Determination of normal values

et al. 2006

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“…The mean ET in our study was 3.71 mm (SD = 1.9) and 92% had an ET ≤5 mm, a finding consistent with numerous studies [11,21,22,23]. Patients in early menopause do not necessarily represent the general postmenopausal population, as there is evidence to suggest that time since menopause is negatively correlated with mean ET [24]. …”

Section: Discussionsupporting

confidence: 89%

Endometrial Thickness in 1,500 Asymptomatic Postmenopausal Women Not on Hormone Replacement Therapy

Hartman

Wolfman

Nayot

et al. 2013

Gynecol Obstet Invest

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Objective: To determine the normal endometrial thickness (ET) on transvaginal ultrasound (TVUS) of asymptomatic postmenopausal women not on hormone replacement therapy. A subgroup that was determined to be suspicious for having an endometrial polyp was compared with the remainder. Methods: This prospective study selected 1,500 consecutive asymptomatic postmenopausal women receiving TVUS assessment from January to August 2010. ET was recorded. Results were divided into those with a normal-appearing lining (n = 1,399) and those suspicious for polyp (n = 101). Results for the entire sample were obtained and the groups were compared using independent samples t tests. Results: Of 1,500 women aged 45-95 years, 77.1% had an ET of ≤4 mm and 92% were ≤5 mm. Independent samples t tests were performed to compare the mean age and mean ET based on polyp status (i.e. with or without a possible polyp). There was a significant difference in mean age, 67.71 vs. 62.36 years (p < 0.01) and mean ET 8.02 vs. 3.40 mm (p < 0.01) between groups. Conclusions: 92% of asymptomatic postmenopausal women not on hormone replacement therapy had an ET of ≤5 mm. The mean ET was 3.71 ± 1.9 mm. However, a significant group, 6.7%, had an endometrial lining suspicious for polyp. These women had a significant increase in mean age and ET.

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“…reported that YSM was a significant variable associated with ET. [18] However, Gull et al . in his study reported that mean ET between women with ≤5 YSM and >5 YSM did not differ significantly (mean [SD] 3.5 [0.2] vs. 3.4 [0.1], P > 0.05).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing endometrial thickness in postmenopausal women

Hebbar

Chaya

Rai

et al. 2014

Ann Med Health Sci Res

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Background:Cut-off values for endometrial thickness (ET) in asymptomatic postmenopausal woman have been standardized. However, there are no comprehensive studies to document how various factors can influence the ET after the age of menopause.Aim:To study the various factors influencing the ET in postmenopausal women.Subjects and Methods:This was a prospective observational study. A total of 110 postmenopausal women underwent detailed history taking, clinical examination, and transvaginal scan for uterine volume and ovarian volume. The volumes were calculated by using ellipsoid formula: Width × thickness × height × 0.523. The variation in ET with respect to the influencing factors such as age, duration of menopause, parity, body mass index (BMI), medical illness like diabetes/hypertension, drugs like tamoxifen, presence of myoma, uterine volume, ovarian volume, and serum estradiol (in selected patients) were measured. Descriptive analysis was performed using SPSS software (version 16, Chicago II, USA) to obtain mean, standard deviation (SD), 95% confidence intervals (CIs) and inter quartile ranges. Comparison of means was carried out using analysis of variance.Results:The mean (SD) age of the patients was 55.4 (6.91) years (95% CI, 54.1, 56.7). The mean (SD) age at menopause was 47.95 (3.90) years (95% CI, 47.2, 48.7) and the mean (SD) duration of menopause was 7.27 (6.65) years (95% CI, 6.01, 8.53). The mean (SD) ET was 3.8 (2.3) mm (95% CI, 3.36, 4.23). Medical illness like diabetes and hypertension did not alter the ET. ET increased as BMI increased and it was statistically significant. The presence of myoma increased uterine volume significantly and was associated with thick endometrial stripe. Similarly, whenever the ovaries were visualized and as the ovarian volume increased, there was an increase in ET. When ET was > 4 mm (n = 37), they were offered endocel, of which 16 agreed to undergo the procedure. None were found to have endometrial cancer.Conclusion:This study suggests that parity, BMI, presence of myoma, tamoxifen usage, uterine volume, ovarian volume and serum estradiol influence the ET in postmenopausal women.

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Improvement of Diagnostic Accuracy of Transvaginal Ultrasound for Identification of Endometrial Malignancies by Using Cutoff Level of Endometrial Thickness Based on Length of Time Since Menopause

Cited by 30 publications

References 0 publications

MR imaging of the uterus and cervix in healthy women: Determination of normal values

MR imaging of the uterus and cervix in healthy women: Determination of normal values

Endometrial Thickness in 1,500 Asymptomatic Postmenopausal Women Not on Hormone Replacement Therapy

Factors influencing endometrial thickness in postmenopausal women

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