2006
DOI: 10.1016/j.vph.2006.01.002
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Improvement of contractility accompanies angiogenesis rather than arteriogenesis in chronic myocardial ischemia

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Cited by 6 publications
(4 citation statements)
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“…(3, 4) This is important because an increased number of capillaries has been correlated with an increase in contractility and function under stress conditions. (5) Endogenous repair machinery is inadequate to correct this deficiency and tremendous resources have been devoted to developing molecular therapies that enhance both the microvascular perfusion and the function of ischemic or infarcted myocardium.…”
Section: Introductionmentioning
confidence: 99%
“…(3, 4) This is important because an increased number of capillaries has been correlated with an increase in contractility and function under stress conditions. (5) Endogenous repair machinery is inadequate to correct this deficiency and tremendous resources have been devoted to developing molecular therapies that enhance both the microvascular perfusion and the function of ischemic or infarcted myocardium.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, conventional revascularization methods do not adequately address the microvascular destruction that accompanies a significant ischemic myocardial injury. 14 These factors have driven investigators to develop novel revascularization techniques that specifically target the microvasculature in ischemic myocardium. 57 …”
mentioning
confidence: 99%
“…For these same reasons, the duration of release of MCP-1 was significantly less than that previously reported for VEGF in the same particle system [7, 30]. Interestingly, short-term expression of MCP-1 has been shown to lead to improved reperfusion in a hindlimb ischemia model [34] while a longer duration of expression yielded no therapeutic benefit in conjunction with FGF-2 delivery [35] despite the established relationship between these two factors [36]. Therefore, it is reasonable to conclude that the duration of release of MCP-1 exhibited by these scaffolds could lead to the therapeutic effects observed in this study.…”
Section: Discussionmentioning
confidence: 99%