Improvement of cerebral ischemia/reperfusion injury by daucosterol palmitate-induced neuronal apoptosis inhibition via PI3K/Akt/mTOR signaling pathway

Zhang, Huiyuan; Song, Yamin; Cong, Feng

doi:10.1007/s11011-020-00575-6

Cited by 22 publications

(14 citation statements)

References 37 publications

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“…However, other interesting effects on stroke-related disorders in preclinical studies have been reported for both hesperidin ( Gaur et al, 2011 ; Ikemura et al, 2012 ; Qin et al, 2020 ) and diosmin ( Delbarre et al, 1995 ; Liu et al, 2014 ). Likewise, sitogluside also exhibited some effects on neurological disorders ( Chung et al, 2016 ; Ji et al, 2017 ; Zhang et al, 2020 ). Adding to this the ability of these molecules to bind the RBD (possible inhibition of SARS-CoV-2-ACE2 interaction), makes these molecules very interesting for exploration for the possibility of repurposing against SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain

Behloul

Baha

Guo

et al. 2021

European Journal of Pharmacology

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The world is currently witnessing the spread of the deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus disease 2019 (COVID-19). In less than three months since the first cases were reported, the World Health Organization declared it a pandemic disease. Although several treatment and prevention strategies are currently under investigation, a continuous effort to investigate and develop effective cures is urgently needed. Thus, we performed molecular docking and structure-based virtual screening of libraries of approved drugs, antivirals, inhibitors of protein-protein interactions, and one million other small molecules to identify strong binders of the SARS-CoV-2 receptor-binding domain (RBD) that might interfere with the receptor recognition process, so as to inhibit the viral cellular entry. According to our screening and selection criteria, three approved antivirals (elbasvir, grazoprevir, and sovaprevir) and 4 other drugs (hesperidin, pamaqueside, diosmin, and sitogluside) were identified as potent binders of the RBD. The binding of these molecules involved several RBD residues required for the interaction of the virus with its cellular receptor. Furthermore, this study also discussed the pharmacological action of the 4 non-antiviral drugs on hematological and neurological disorders that, in addition to inhibiting the viral entry, could be beneficial against the neurological disorders identified in COVID-19 patients. Besides, six other small-molecules were identified, with no pharmacological description so far, exhibiting strong binding affinities to the RBD that we believe worth being investigated as inhibitors of the SARS-CoV-2-receptor interaction.

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Section: Discussionmentioning

confidence: 99%

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain

Behloul

Baha

Guo

et al. 2021

European Journal of Pharmacology

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“…A study found that activating PI3K/ Akt signal pathway could inhibit the apoptosis of nerve and reduce the occurrence of blood-borne brain edema. A series of studies have shown that many Chinese herbal extracts play a protective role in IS through this pathway [62,63]. Another study found that baicalein also decreased the LC3-II/LC3-I ratio and promoted phosphorylation of the PI3K/ Akt/mTOR signaling pathway which implied inhibition of autophagy.…”

Section: Discussionmentioning

confidence: 98%

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke

Gao

Tian

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background and Objective. With the exact clinical efficacy, Buyang Huanwu decoction (BHD) is a classical prescription for the treatment of ischemic stroke (IS). Here, we aimed to investigate the pharmacological mechanisms of BHD in treating IS using systems biology approaches. Methods. The bioactive components and potential targets of BHD were screened by TCMSP, BATMAN-TCM, ETCM, and SymMap databases. Besides, compounds that failed to find the targets from the above databases were predicted through STITCH, SwissTargetPrediction, and SEA. Moreover, six databases were searched to mine targets of IS. The intersection targets were obtained and analyzed by GO and KEGG enrichment. Furthermore, BHD-IS PPI network, compound-target network, and herb-target-pathway network were constructed by Cytoscape 3.6.0. Finally, AutoDock was used for molecular docking verification. Results. A total of 235 putative targets were obtained from 59 active compounds in BHD. Among them, 62 targets were related to IS. PPI network showed that the top ten key targets were IL6, TNF, VEGFA, AKT1, etc. The enrichment analysis demonstrated candidate BHD targets were more frequently involved in TNF, PI3K-Akt, and NF-kappa B signaling pathway. Network topology analysis showed that Radix Astragali was the main herb in BHD, and the key components were quercetin, beta-sitosterol, kaempferol, stigmasterol, etc. The results of molecular docking showed the active components in BHD had a good binding ability with the key targets. Conclusions. Our study demonstrated that BHD exerted the effect of treating IS by regulating multitargets and multichannels with multicomponents through the method of network pharmacology and molecular docking.

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“…Previous studies have demonstrated that various elements serve neuroprotective roles in cerebral I/R injury models, such as tamibarotene ( 34 ), daucosterol ( 35 ) and orally administered crocin ( 36 ). Zhang et al ( 36 ) reported that orally administered crocin exerted protective effects against cerebral I/R injury via metabolic transformation of crocetin by the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Protective role of lidocaine against cerebral ischemia‑reperfusion injury: An in vitro study

Lan

2021

Exp Ther Med

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Improvement of cerebral ischemia/reperfusion injury by daucosterol palmitate-induced neuronal apoptosis inhibition via PI3K/Akt/mTOR signaling pathway

Cited by 22 publications

References 37 publications

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke

Protective role of lidocaine against cerebral ischemia‑reperfusion injury: An in vitro study

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