Improvement of cardiac function in fetuses with growth restriction following antenatal betamethasone administration: fact or artifact?

P, Vadivelu; Keepanasseril, Anish; Plakkal, Nishad

doi:10.1080/14767058.2019.1683538

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…Similarly to our study, Marchi et al reported no significant change in MPI values between groups. Consistent with the literature [11,12], in our study we detected no change in TV Doppler parameter values. Güngör et al reported that there was no change in pulmonary artery branch indices [9].…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, betamethasone could influence brain circulation. Concordant with the literature, DV PI remained unchanged in the present study [11,12,14,15].…”

Section: Division Of Worksupporting

confidence: 93%

“…Several studies have reported the effect of betamethasone on Doppler parameters of the MCA, and they found decreased or unchanged MCA PI levels in various patient groups [5,6,11,12,15]. In our study, except for MCA S/D, all other MCA Doppler indices had a significant change.…”

Section: Division Of Worksupporting

confidence: 58%

“…This corticosteroidinduced change might cause a reduction in pulmonary vascular resistance. Another cardiac parameter was the myocardial performance index (MPI), which reflects combined systolic and diastolic performance [11]. Vadivelu et al reported that MPI was lower after steroid administration in an FGR group.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Does betamethasone therapy impact fetal multivessel Doppler parameters?

Özdemir¹,

Çalış²,

Karçaaltıncaba³

et al. 2021

pcard

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Introduction: The objective of this study was to test the hypothesis that antenatal corticosteroid therapy alters fetal cardiopulmonary and uteroplacental blood flow in pregnancies. Material and methods: Twenty-seven singleton pregnancies between 28 and 34 gestational weeks classified as at risk of preterm birth were included prospectively. We evaluated fetal main pulmonary artery (MPA), left and right pulmonary artery (PA), left myocardial performance index (Tei index), tricuspid valve (TV), umbilical artery (UmA), middle cerebral artery (MCA), and ductus venosus (DV) parameters before and 48 hours and 7 days after antenatal steroid administration. Results: The mean age was 31 years, and the mean gestational age was 31 weeks. The UmA S/D (Systole/Diastole) ratio, PI (pulsatility index) and RI (resistive index) values, and Doppler parameters of other vessels were not different when comparing between before and after steroid administration. Except for MCA PSV (peak systolic velocity) values, the other MCA Doppler parameters (S/D, PI, RI) were all significantly decreased. The cerebroplacental ratio (CPR) and CPR percentile values decreased significantly. All tested cardiac parameters were unchanged, except MPA ejection time (ET) (p = 0.016). Conclusions: Our data demonstrate altered fetal MCA and CPR with corticosteroid therapy. These data suggest that antenatal corticosteroid therapy has no impact on any Doppler parameters of fetal cardiopulmonary and uteroplacental blood flow in pregnancies.

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Section: Discussionsupporting

confidence: 93%

“…Therefore, betamethasone could influence brain circulation. Concordant with the literature, DV PI remained unchanged in the present study [11,12,14,15].…”

Section: Division Of Worksupporting

confidence: 93%