Improvement of Bone Strength and Dermal Thickness Due to Dietary Edible Bird’s Nest Extract in Ovariectomized Rats

Matsukawa, Noriko; Matsumoto, Megumi; Bukawa, Wakoto; Chiji, Hideyuki; Nakayama, Katsuhiro; Hara, Hiroshi; Tsukahara, Takamitsu

doi:10.1271/bbb.100705

Cited by 82 publications

(41 citation statements)

References 21 publications

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“…Edible bird's nest has lethal dose (LD 50 ) cut off more than 5,000 mg/kg and is classified as category 5 or unclassified category of globally harmonized classification system (GHS), therefore it is safe to be taken by to humans (Haghani et al, 2016). Furthermore, there are scientific reports of its anti-oxidative, anti-inflammatory, influenza virus inhibitory effect, hemagglutination-inhibitory activities, and bone-strengthening effects (Kong et al, 1987;Guo et al, 2006;Matsukawa et al, 2011;Ma and Liu, 2012;Vimala et al, 2012;Yida et al, 2014). In 2015, Yida et al showed that edible bird's nest prevents high-fat diet-(HFD) induced insulin resistance in rats.…”

Section: Introductionmentioning

confidence: 99%

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

et al. 2020

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Increased oxidative stress by hyperglycemia is a major cause of vascular complications in diabetes. Bird's nest, which is made from the saliva of swiftlets has both medicinal and nutritional values dated back to ancient China. However, its role in improving endothelial dysfunction due to diabetes is yet to be elucidated. The present study examined the protective effect and mechanism of action of the aqueous extract of hydrolyzed edible bird nest (HBN) on endothelium in models of diabetes, in vitro and in vivo. Male db/m+ and db/ db mice were orally administered with or without HBN and glibenclamide for 28 days, followed by vascular reactivity studies in mouse aortas. Human umbilical vein endothelial cells (HUVECs) and isolated mouse aorta from C57BL/6J were treated with high glucose (HG), HBN, sialic acid (SA), glibenclamide, and apocynin, respectively. The effects of HBN on reactive oxygen species (ROS) production and nitric oxide (NO) bioavailability were assessed by Western blot, 2′,7′-dichlorofluorescin-diacetate (DCF-DA), and 4-amino-5methylamino-2′,7′ difluorofluorescein (DAF-FM DA) in HUVECs, isolated mouse aorta, and db/db diabetic mice. HBN significantly reversed the endothelial dysfunction in diabetic mice and isolated mouse aorta. HBN normalized ROS overproduction of NOX2 and nitrotyrosine, reversed the reduction of anti-oxidant marker, SOD-1 as well as restored NO bioavailability in both HUVECs challenged with HG and in db/db diabetic mice. Similarly, HG-induced elevation of oxidative stress in HUVECs were reversed by SA, glibenclamide, and apocynin. This attests that HBN restores endothelial function and protects endothelial cells against oxidative damage induced by HG in HUVECs, isolated mouse aorta, and db/ db diabetic mice via modulating ROS mechanism, which subsequently increases NO bioavailability. This result demonstrates the potential role of HBN in preserving endothelial function and management of micro-or macrovascular complications in diabetes.

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Section: Introductionmentioning

confidence: 99%

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

et al. 2020

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“…Recent research suggests that EBNs and EBN extracts have interesting bioactive properties (Ng et al, 1986;Kong et al, 1987;Guo et al, 2006;Yagi et al, 2008;Aswir and Wan Nazaimoon, 2011;Abidin et al, 2011;Matsukawa et al, 2011;Vimala et al, 2011;Roh et al, 2012;Zhang et al, 2012). Recent research suggests that EBNs and EBN extracts have interesting bioactive properties (Ng et al, 1986;Kong et al, 1987;Guo et al, 2006;Yagi et al, 2008;Aswir and Wan Nazaimoon, 2011;Abidin et al, 2011;Matsukawa et al, 2011;Vimala et al, 2011;Roh et al, 2012;Zhang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Edible bird's nests—How do the red ones get red?

But

Jiang

Shaw

2013

Journal of Ethnopharmacology

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“…Dermal thickness was shown to be thickened in rats fed with EBN extract whereas serum estradiol levels remain the same. [99] The EBN supplementation may improve skin ageing and enhance bone strength. However, a case of allergens was occurred upon the consumption of EBN by causing anaphylaxis, mostly among children, where most are from the cave EBN.…”

Section: Undesirable Reaction During Production Of Ebn Bioactive Glycmentioning

confidence: 99%

Edible Bird’s Nest: Physicochemical Properties, Production, and Application of Bioactive Extracts and Glycopeptides

Daud

Yusop

Babji

et al. 2019

Food Reviews International

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Edible bird's nest (EBN), the swiftlet's nest, has been consumed for centuries as a tonic or health food. The information upon the usage and benefits of the EBN are largely based on historical and observational reports since its discovery, until some were proven scientifically at recent times. Studies have been conducted on the major components of the EBN, i.e. glycoprotein, in attempts to elucidate the roles of the glycoprotein in terms of functionality toward health improvement. This article presents a review of the physicochemical and nutritional composition of EBN from different harvested locations and its functional properties. The conversion of EBN glycoproteins to glycopeptides via suitable hydrolysis methods to produce bioactive EBN glycopeptides was demonstrated, and it showed improvements in the functionality and nutritional values of EBN. Some applications of EBN glycopeptides into the new development of food and beverage products showed positive results, implicated to the bioavailability of the EBN glycopeptides. The combined information in this review will benefit the scientific communities, EBN manufacturers, and nutraceutical industries.

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Improvement of Bone Strength and Dermal Thickness Due to Dietary Edible Bird’s Nest Extract in Ovariectomized Rats

Cited by 82 publications

References 21 publications

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

Edible Bird’s Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction

Edible bird's nests—How do the red ones get red?

Edible Bird’s Nest: Physicochemical Properties, Production, and Application of Bioactive Extracts and Glycopeptides

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