Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique

Jayan, Heera; Leena, M. Maria; Sundari, S.K. Sivakama; Moses, J.A.; Anandharamakrishnan, C.

doi:10.1016/j.jff.2019.04.007

Cited by 103 publications

(45 citation statements)

References 45 publications

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“…Antioxidant activity of the developed films was performed via 2,2‐diphenyl‐picrylhydrazyl (DPPH) radical scavenging assay as reported previously (Jayan et al , ). In brief, 3 mL of 10 −4 m of freshly prepared DPPH solution, using methanol as solvent, was taken in test tubes containing 5 mg of film samples.…”

Section: Methodsmentioning

confidence: 99%

Nanofibre‐based bilayer biopolymer films: enhancement of antioxidant activity and potential for food packaging application

Bharathi

Leena

Moses

et al. 2020

Int J of Food Sci Tech

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Summary This study aimed to enhance the antioxidant property of biopolymer film without the incorporation of external agents. The active bilayer film with improved antioxidant activity has been developed by electrospinning zein, a prolamine of corn as nanofibre (average diameter of 286 nm) on solvent cast chitosan film. Zein nanofibres exhibited a slight increase in antioxidant activity as compared to solvent cast zein film. But, zein nanofibre coating on chitosan films significantly improved its antioxidant activity from 12.41% to 44.17%. The developed bilayer films were evaluated for its ability to prevent browning in minimally processed apple slices and compared with those of chitosan and zein films plasticised with polyethylene glycol. Higher surface to volume ratio and better affinity of zein nanofibres in the bilayer film helped enhance its anti‐browning ability. Thus, zein nanofibre‐coated chitosan bilayer films can be used as an effective anti‐browning packaging material for the packing of minimally processed fruits.

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Section: Methodsmentioning

confidence: 99%

Nanofibre‐based bilayer biopolymer films: enhancement of antioxidant activity and potential for food packaging application

Bharathi

Leena

Moses

et al. 2020

Int J of Food Sci Tech

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“…Jayan et al. informed that encapsulated resveratrol enhanced the bioavailability (1.15‐fold) in the small intestinal system compared to the free resveratrol (Jayan, Leena, Sundari, Moses, & Anandharamakrishnan, 2019).…”

Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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Botanic bioactive substances have issues with their solubility, stability, and oral bioavailability in the application, which could be improved by nanotechnologies. In another hands, green synthesis of nanoparticles (NPs) with plant extract is also a promising technology for preparation of NPs due to its safety advantage, yet the bioactive botanic substances that could be more than the assistant of the green synthesis of NPs. Based on the above concerns, this review summarized the preparation of botanic NPs with various plant extract, their solubility, stability, and oral bioavailability; specific attention has been paid to the botanic Ag/Au NPs, their capacity of antioxidant, bioavailability, antimicrobial, anti‐inflammatory, and anticancer.

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“…Moreover, there are also many reports that ZNPs can increase cell uptake (Zhang et al, 2016). Hashem et al and Jayan et al encapsulated resveratrol into zein nanoparticles, which improved mucoadhesive properties and tissue permeability, thereby increasing oral bioavailability (Hashem et al, 2015;Jayan et al, 2019). Another study showed that TPGS-coated zein nanoparticles significantly increased cellular uptake and membrane permeation (Zou & Gu, 2013).…”

Section: Discussionmentioning

confidence: 99%

Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer

et al. 2019

Drug Delivery

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2020) Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer, Drug Delivery, 27:1, 100-109, ABSTRACT Purpose: Maytansine (DM1) is a potent anticancer drug and limited in clinical application due to its poor water solubility and toxic side effects. Zein is widely used in nano drug delivery systems due to its good biocompatibility. In this study, we prepared DM1-loaded zein nanoparticles (ZNPs) to achieve tumor targeting and reduce toxic side effects of DM1. Methods: ZNPs were prepared by phase separation and Box-Behnken design was used to optimize the formulation. Then, confocal fluorescence microscope and flow cytometry were used to determine cellular uptake of ZNPs. A549 cells were cultured in vitro to study cytotoxicity and used to establish tumor xenografts in nude mice. Biodistribution and antitumor activity of ZNPs were performed in vivo experiments. In addition, we also performed histological and immunohistochemical examinations on tumors and viscera. Results: The optimal prescription was obtained by using 120 lL zein added to 2 mL water under stirring in 300 rpm. The encapsulation efficiency and drug loading were 82.97 ± 0.80% and 3.32 ± 0.03%, respectively. We found that DM1-loaded ZNPs have a strong inhibitory effect on A549 cells, which stemmed from the ability of ZNPs to enhance cellular uptake. Furthermore, we demonstrated that DM1-loaded ZNPs exhibits a better antitumor efficacy than DM1, which tumor inhibition rate were 97.3% and 92.7%, respectively. The biodistribution revealed that ZNPs could targeted to tumor. Finally, we confirmed by histological that DM1-loaded ZNPs are nontoxic. Conclusion: DM1-loaded ZNPs have considerable antitumor activity. Thus, DM1-loaded ZNPs are a promising treatment of non-small cell lung cancer. ARTICLE HISTORY

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Improvement of bioavailability for resveratrol through encapsulation in zein using electrospraying technique

Cited by 103 publications

References 45 publications

Nanofibre‐based bilayer biopolymer films: enhancement of antioxidant activity and potential for food packaging application

Nanofibre‐based bilayer biopolymer films: enhancement of antioxidant activity and potential for food packaging application

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer

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