Improvement of Bacterial Vaginosis by Oral Lactobacillus Supplement: A Randomized, Double-Blinded Trial

Abstract

Bacterial vaginosis (BV) is the most common vaginal infection globally, with a high recurrent rate after antibiotic treatment. Probiotics consumption is known to improve BV with different efficacy among species or strains. After in vitro selection of Lactobacillus strains with growth inhibition and preventing adhesion to HeLa cervical epithelial cells, a randomized and double-blinded trial of two Lactobacillus formula, namely, VGA-1 and VGA-2, in BV patients with Nugent scores of 4–10 was conducted. Among 37 subjects who completed the trial, we observed significantly decreased Nugent scores in both VGA-1 (n = 18) and VGA-2 (n = 19) consumption groups. VGA-1 consumption significantly improved vaginal discharge odor/color and itching at both 2-week and 4-week-consumption, but those only observed after a 4-week-consumption in the VGA-2 group. We also observed a tendency to reduce recurrent rates among enrolled participants after VGA-1 or VGA-2 consumption. The improvement effect of VGA-1/VGA-2 was associated with the significant reduction of interleukin-6 expression after 4-week-consumption and the restoration of normal vaginal microflora by quantitative polymerase chain reaction analysis. In conclusion, VGA-1 or VGA-2 displayed beneficial effects in BV patients, but the VGA-1 formula showed a better efficacy, potentially used for BV intervention.

Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons

“…GMNL-185 and GMNL-680 are known to improve bacterial vaginosis by which GMNL-185 inhibits the growth of Gardnerella vaginalis ( G. vaginalis ) and GMNL-680 inhibits Streptococcus agalactiae ( S. agalactiae ) and Staphylococcus aureus ( S. aureus ). 68 Moreover, GMNL-185 plays roles for modifying the gut microbiota to decrease the levels of depression-related metabolites 69 or inhibit the growth of Helicobacter pylori ( H. pylori ) in mice, thereby, ameliorating inflammation in stomach. 70 GMNL-185 strain has potentials of anti-depressive and treated of gastrointestinal diseases.…”

Hormonal status in women of reproductive age with nonspecific vaginitis

“…Питому вагу серед них мають бактеріальний вагіноз (БВ) та аеробний вагініт (АВ). За даними літератури, бактеріальний вагіноз зустрічається від 15% до 50% випадків серед жінок репродуктивного віку в усьому світі [1,2]. Аеробний вагініт виявляється у 8-11% вагітних жінок та в 5-24% жінок, які скаржаться на вагінальні виділення [3,4].…”

Probiotics and Microbiota-Derived Molecules for Inflammation, Neuroinflammation and Mood Disorders

“…In their article, Lin et al [5] presented a study on the benefits of oral use of Lactobacillus in human bacterial vaginosis. The authors conduct a randomized, double-blind study using two formulas of Lactobacillus in patients with bacterial vaginosis.…”