Improvement of B Cell Responses by an HIV-1 Amphiphilic Polymer Nanovaccine

Xin, Xiaoqian; Liu, Yifeng; Guo, Lei; Wang, Hui; Lu, Daiqiang; Chang, Yaotian; Wan, Mingming; Zhang, Yong; Shan, Yaming; Zhang, Qiao; Liu, Xiaowen; Gao, Feng

doi:10.1021/acs.nanolett.3c01241

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…This new approach demonstrates a great potential to improve nAb responses induced by HIV-1 vaccines. Continued optimization the Env trimer design such as by developing more stable UFO-BG trimers, Env trimers with a better exposed “up” position V2-apex [ 28 ] or nanoparticle vaccine approaches [ 56 ] may further improve the immunogenicity of the current approach.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Wan

Xiao

Sun

et al. 2023

IJMS

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HIV-1 vaccines have been challenging to develop, partly due to the high level of genetic variation in its genome. Thus, a vaccine that can induce cross-reactive neutralization activities will be needed. Studies on the co-evolution of antibodies and viruses indicate that mimicking the natural infection is likely to induce broadly neutralizing antibodies (bnAbs). We generated the consensus Env sequence for each time point in subject CH505, who developed broad neutralization activities, and selected five critical time points before broad neutralization was detected. These consensus sequences were designed to express stable Env trimers. Priming with the transmitted/founder Env timer and sequential boosting with these consensus Env trimers from different time points induced broader and more potent neutralizing activities than the BG505 Env trimer in guinea pigs. Analysis of the neutralization profiles showed that sequential immunization of Env trimers favored nAbs with gp120/gp41 interface specificity while the BG505 Env trimer favored nAbs with V2 specificity. The unique features such as consensus sequences, stable Env trimers and the sequential immunization to mimic natural infection likely has allowed the induction of improved neutralization responses.

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Section: Discussionmentioning

confidence: 99%

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Wan

Xiao

Sun

et al. 2023

IJMS

Self Cite

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“…127 A glycoprotein-based NP vaccine with HIV-1 envelope designed with amphiphilic polymer which showed an enhanced response by neutralizing the potency. 128 3.4. Malaria (P. falciparum).…”

Section: Aids (Hiv)mentioning

confidence: 99%

“…A conclusion was drawn that it can eventually be useful in humans . A glycoprotein-based NP vaccine with HIV-1 envelope designed with amphiphilic polymer which showed an enhanced response by neutralizing the potency …”

Section: Specific Diseasesmentioning

confidence: 99%

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

Patra,

Pareek,

Gupta

et al. 2024

ACS Infect. Dis.

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In this era of advanced technology and innovation, infectious diseases still cause significant morbidity and mortality, which need to be addressed. Despite overwhelming success in the development of vaccines, transmittable diseases such as tuberculosis and AIDS remain unprotected, and the treatment is challenging due to frequent mutations of the pathogens. Formulations of new or existing drugs with polymeric materials have been explored as a promising new approach. Variations in shape, size, surface charge, internal morphology, and functionalization position polymer particles as a revolutionary material in healthcare. Here, an overview is provided of major diseases along with statistics on infection and death rates, focusing on polymer-based treatments and modes of action. Key issues are discussed in this review pertaining to current challenges and future perspectives.

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“…The HIV P24-Nef/FLiC/PLGA nanoparticle vaccine enhanced the immunogenicity of the antigen and reduced the required antigenic dose, resulting in heightened cellular immune responses. Another study conjugated poly (maleic anhydride-ALT-1-octadecene) (PMHC 18 ) with poly (ethylene glycol) (PEG) to synthesize the amphiphilic polymer (P 1 M 10 ) nano-carriers for HIV vaccines [ 193 ]. The HIV Env nanoparticles (Env/NPs) produced utilizing P 1 M 10 induced more potent and broader neutralizing antibodies against various HIV subtypes.…”

Section: The Applications Of Nanoparticles In Hiv Vaccinesmentioning

confidence: 99%

Nanoparticles and Antiviral Vaccines

Liu,

Hu,

Liu

et al. 2023

Vaccines

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Viruses have threatened human lives for decades, causing both chronic and acute infections accompanied by mild to severe symptoms. During the long journey of confrontation, humans have developed intricate immune systems to combat viral infections. In parallel, vaccines are invented and administrated to induce strong protective immunity while generating few adverse effects. With advancements in biochemistry and biophysics, different kinds of vaccines in versatile forms have been utilized to prevent virus infections, although the safety and effectiveness of these vaccines are diverse from each other. In this review, we first listed and described major pathogenic viruses and their pandemics that emerged in the past two centuries. Furthermore, we summarized the distinctive characteristics of different antiviral vaccines and adjuvants. Subsequently, in the main body, we reviewed recent advances of nanoparticles in the development of next-generation vaccines against influenza viruses, coronaviruses, HIV, hepatitis viruses, and many others. Specifically, we described applications of self-assembling protein polymers, virus-like particles, nano-carriers, and nano-adjuvants in antiviral vaccines. We also discussed the therapeutic potential of nanoparticles in developing safe and effective mucosal vaccines. Nanoparticle techniques could be promising platforms for developing broad-spectrum, preventive, or therapeutic antiviral vaccines.

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Improvement of B Cell Responses by an HIV-1 Amphiphilic Polymer Nanovaccine

Cited by 6 publications

References 18 publications

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

Nanoparticles and Antiviral Vaccines

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