Improvement of Antifungal Activity of 10-Undecyn-1-ol by Inclusion Complexation with Cyclodextrin Derivatives

Neoh, Tze Loon; Tanimoto, Takahiro; Ikefuji, Shuichi; Yoshii, Hidefumi; Furuta, Takeshi

doi:10.1021/jf0731898

Cited by 9 publications

(6 citation statements)

References 33 publications

(45 reference statements)

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“…SAS1 has previously been identified by GC‐MS as one of the phytochemical constituents of the plant Sarcostemma secamone (Kumari, Muthukumarasamy, & Mohan, ). This compound, which was also isolated in the leaf extracts of Azadirachta indica has limited solubility in water and has been determined to have antifungal activity (Neoh, Tanimoto, Ikefuji, Yoshii, & Furuta, ). Prior to this study, there has not been a report of the production of 10‐Undecyn‐1‐ol by a Penicillium species or by microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Potential biotechnological capabilities of cultivable mycobiota from carwash effluents

Sibanda¹,

Selvarajan²,

Tekere³

et al. 2017

MicrobiologyOpen

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Urban life has created man‐made extreme environments like carwashes. These environments have, however, not been sufficiently explored for mycobiota that can be sources of biotechnologically useful products, as has been the case with natural extreme environments. Using a combination of culture and molecular techniques, fungi from carwash effluents was characterized for production of lipase and cellulase enzymes, nonpolar and polar biotechnologically relevant secondary metabolites and hydrocarbon utilization. The isolated fungal strains belonged to the genera Alternaria, Cladosporium, Penicillium, Peyronellaea, Rhizopus, Spegazzinia, Trichoderma, Ulocladium and Yarrowia. Sixty‐six percent (66%) of the fungal isolates were found to be able to metabolize naphthalene and benzanthracene, showing potential for application in bioremediation of hydrocarbon polluted sites. Lipase production by the isolates Penicillium sp. BPS3 (2.61 U/ml), Trichoderma sp. BPS9 (2.01 U/ml), Rhizopus sp. CAL1 (2.05 U/ml), Penicillium sp. PCW1 (2.99 U/ml) and Penicillium sp. SAS1 (2.16 U/ml) compared well with previously recorded lipase production levels by other fungi. The highest producers of cellulase were Penicillium sp. SAS1 (12.10 U/ml), Peyronella sp. CAW5 (4.49 U/ml) and Cladosporium sp. SAS3 (4.07 U/ml), although these activities were lower than previously reported levels. GC‐MS analysis of the fungal secondary metabolites resulted in identification of 572 compounds, including azulene, methanamine, N‐pentylidene, metoclopramide, and mepivacaine while compounds determined by UHPLC‐MS included 10‐undecen‐1‐ol, piquerol A, 10‐undecyn‐1‐ol, cyclo(leucylprolyl) and rac‐etomidate. These compounds were previously determined to have various activities including anticancer, antibacterial, antifungal, antihypertensive, antidiabetic and anti‐inflammatory properties. The study demonstrated that fungi from carwash effluents are natural sources of some biotechnologically important products.

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Section: Discussionmentioning

confidence: 99%

Potential biotechnological capabilities of cultivable mycobiota from carwash effluents

Sibanda¹,

Selvarajan²,

Tekere³

et al. 2017

MicrobiologyOpen

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“…1,8-Nonadiyne is reported to undergo one-step hydrosilylation reaction for attaching acetylene-terminated alkyl monolayers to nonoxidized crystalline silicon surfaces [17]. 10-Undecyn-1-ol has been reported to possess antifungal activity [18]. Some of these properties of the constituents detected in crude oil showed that it may be useful as or in production of certain antifungal.…”

Section: Discussionmentioning

confidence: 99%

Detection and Analysis of Mineral Elements in Giant Embryo Rice

Peng¹,

Xu²,

He³

et al. 2020

JBR

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Mineral elements are essential micronutrients necessary to constitute human tissue and maintain normal physiological functions. Micronutrient deficiencies are an important issue currently faced in the world. The best strategy to solve this problem is to breed special functional types of rice varieties rich in trace elements (special rice for short). A special type of rice that can produce rich nutrients. In order to explore the nutritional value of giant embryo rice, the contents of 17 mineral elements ((K, Ca, Fe, Se, Zn, Cu, Na, Mn, Mg, Ni, Cr, Co, Pb, As, Cd, Ag, Al)) in 5 kinds of giant embryo rice (white giant embryo, giant japonica-GB-12, giant japonica-GB-11 and giant japonica-GB-5, giant japonica-GB-1) were detected by inductively coupled plasma mass spectrometry. After comparison with ordinary rice, it was found that the content of the same mineral element in different samples has a large variation, suggesting that different rice varieties have different absorption, transformation and storage efficiency of the same element; different giant embryo brown rice in some mineral elements (such as Cr, Ni, Cu and Zn) are extremely low in content and almost undetectable. Meanwhile, the brown rice of giant embryo rice has a more powerful enrichment effect on some mineral elements, which means that embryo rice has a unique advantage in cultivating new rice varieties with special functions rich in minerals.

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“…Biological activities of some of the compounds identified in the avocado seed oil have been reported in literature. One of the major bioactive components of the oil, 10-Undecyn-1-ol, has been found to exhibit antifungal activity (Neoh et al, 2008). Devi and Serfoji (2018) have reported the antioxidant, hypocholesterolemic, antiandrogenic, hemolytic and alpha reductase inhibitory activities of 7-Hexadecenoic acid, methyl ester.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Determination of Bioactive Constituents and Mineral Contents of Avocado Pear Seed Oil

Adaramola¹,

Shadrach²,

Adegoke³

et al. 2023

dujopas

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Edible oils of plant origins are fundamental components of human diet, and are essential for various industrial applications, such as in food, cosmetics, and pharmaceutical industries. Of increasing interest is the utilization of edible oils obtained from plant parts such as peels, seeds, rinds, leaves, flowers, and fruits, which are usually regarded as wastes. This study investigated the usability of edible oil extracted from avocado pear seed by assaying its bioactive constituents and mineral composition. The bioactive compounds in the oil were determined by Gas Chromatography Mass Spectroscopy (GC-MS), while the mineral content was assayed using Atomic Absorption Spectrometry (AAS). Results of the GC-MS analysis showed the presence of twenty nine compounds, with 18-Nonadecen-1-ol (13.20%) being the most predominant, and 3,7,7-Trimethyl-1,3,5-cycloheptatriene (0.24%) the least. Compounds such as 10-Undecyn-1-ol, 7-Hexadecenoic acid methyl ester, 14-methyl Pentadecanoic acid methyl ester, and Linolelaidic acid, methyl ester, identified in the avocado seed oil, have previously been reported to possess various biological activities, including antifungal, antioxidant, antimicrobial, hypocholesterolemic, antiandrogenic, hemolytic, anti-cancer and anti-inflammatory activities. Results of the mineral analysis showed that potassium (13.09 ± 0.22 mg/100 g) was the major element, while copper (0.06 ± 0.11 mg/ 100 g) was the least; cadmium and lead were not detected in the oil. The presence of pharmacologically important phytochemicals and essential minerals in avocado seed oil suggests its potential as a nutraceutical substance, with applications in food and drug preparations.

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Improvement of Antifungal Activity of 10-Undecyn-1-ol by Inclusion Complexation with Cyclodextrin Derivatives

Cited by 9 publications

References 33 publications

Potential biotechnological capabilities of cultivable mycobiota from carwash effluents

Potential biotechnological capabilities of cultivable mycobiota from carwash effluents

Detection and Analysis of Mineral Elements in Giant Embryo Rice

Determination of Bioactive Constituents and Mineral Contents of Avocado Pear Seed Oil

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