Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique

Pund, Swati; Borade, Ganesh; Rasve, Ganesh

doi:10.1016/j.phymed.2013.09.013

Cited by 69 publications

(46 citation statements)

References 34 publications

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“…Various nano-particulate delivery systems have been used to increase the absorption of berberine, including the rotary-evaporated film-ultrasonication method [260], nanoemulsification with isopropyl myristate/glycerin [261], and lipisomal incorporation [262]. Berberine manufactured with the nanoparticulate delivery systems demonstrated improved bioavailability and optimization of its anti-inflammatory, anti-angiogenic [263], and anticancer effects [264]. Berberine has potential as an anti-cancer agent [250].…”

Section: Approachesmentioning

confidence: 99%

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey

Amedei

Aquilano

et al. 2015

Seminars in Cancer Biology

304

204

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Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adapative immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2, 3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer.

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Section: Approachesmentioning

confidence: 99%

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey

Amedei

Aquilano

et al. 2015

Seminars in Cancer Biology

304

204

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“…d 50 is the mean particle size. d 10 and d 90 are the size of the particles below 10% and 90% respectively of the sample lies [16].…”

Section: Particle Size Characterizationmentioning

confidence: 99%

Mechanistic investigation of biopharmaceutic and pharmacokinetic characteristics of surface engineering of satranidazole nanocrystals

Dhat

Pund

Kokare

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…The nanoberberine was added to a phosphate buffer and in 45 minutes, 85% of the compound dissolved, compared to only 60% of the free berberine in the same time period. 64 Other classes of natural compounds, such as tannins and terpenoids, are highly hydrophilic. These compounds have low bioavailability because they cannot cross biological membranes.…”

Section: Bioavailabilitymentioning

confidence: 99%

Natural product-based nanomedicine: recent advances and issues

Watkins¹,

Wu²,

Zhang³

et al. 2015

IJN

157

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Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications.

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Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique

Cited by 69 publications

References 34 publications

Cancer prevention and therapy through the modulation of the tumor microenvironment

Cancer prevention and therapy through the modulation of the tumor microenvironment

Mechanistic investigation of biopharmaceutic and pharmacokinetic characteristics of surface engineering of satranidazole nanocrystals

Natural product-based nanomedicine: recent advances and issues

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