Improvement of Amperometric Biosensor Performance for H₂O₂Detection based on Bimetallic PtM (M = Ru, Au, and Ir) Nanoparticles

Abstract

Novel bimetallic nanoparticles have been synthesized via rapid microwave irradiation, leading to an improved sensitivity and a highly anti-interference property for amperometric biosensor in H2O2detection. The material characterizations were performed by TEM, XRD, and EDX, which show the bimetallic formation of Pt-based catalysts and well-dispersed nanoparticles of 2–5 nm. The sensitivities for the detection of H2O2of PtRu, PtAu, and PtIr as the biosensor working electrode catalysts are 539.01 (R2=0.99), 415.46 (R2=0.99), and 404.52 (R2=0.97) μA mM−1 cm-2, respectively, nearly twice higher than the pure Pt catalyst (221.77 μA mM−1 cm−2,R2=0.98), at a low applied potential of +0.25 V versus Ag/AgCl. Furthermore, Pt-Ru and Pt-Ir show a highly sensitive response and a promising anti-interference capability to ascorbic acid, a major interferent, by reducing the interferent current as low as 7-8% significantly lower than that of Pt (30% change). The enhancement of both sensitivity and selectivity in the bimetallic catalysts can be found practical applications in biosensing.

Monodisperse AuM (M=Pd, Rh, Pt) bimetallic nanocrystals for enhanced electrochemical detection of H2O2

“…However, the catalytic properties of single Au nanoparticles were undesirable for practical applications [18,19]. Additionally, some interfering species like ascorbic acid (AA) coexisted in the biological fluid would affect the detection of biosensors based on gold nanoparticles [20]. It is known that bimetallic catalysts offered new properties which were distinct from the single metal [21,22], and leaded to more efficiency in various bio-sensing systems.…”

Nanostructures in Hydrogen Peroxide Sensing

“…Zhang et al [ 53 ] synthesized bimetallic nanoparticles for the amperometric sensor in H O detection. Three bimetallic nanoparticles (platinum + ruthenium, PtRu, platinum + gold, PtAu and platinum + iridium, PtIr) were synthesized by a very interesting method that employs microwave irradiation.…”

Pt-MWCNT modified carbon electrode strip for rapid and quantitative detection of H 2 O 2 in food

“…H 2 O 2 as a product generated from human body or enzymatic reaction is a valuable biomarker of inflammation [ 1 , 2 ], some chronic diseases [ 3 – 5 ], and an essential mediator in food [ 6 ], industry, medical, and environmental analysis [ 7 , 8 ]. Therefore, developing a reliable, sensitive, rapid and low-cost sensor for detecting H 2 O2 has become an area of increased importance in recent years [ 9 – 15 ]. There already have various colorimetric, fluorescence, and electrochemical methods been developed to detect the H 2 O 2 concentration.…”