Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet.

A randomized controlled study comparing elemental diet and steroid treatment in Crohn's disease

“…35 Elemental diets have also been demonstrated to be effective in improving intestinal permeability. 11,13 In a recent study, Teahon et al tried to determine the importance of nutritional factors in inducing remission from the disease: they concluded that the fact that changes in disease activity appear to precede any detectable changes in nutritional state suggest that the bene®cial action of elemental diet in patients with active Crohn's disease is not due to an improvement in nutritional status. 36 We performed this controlled study with the aim of better de®ning a relatively simple route of administration, i.e.…”

“…Although the mechanism is unknown, it has been shown that treatment with an elemental diet reduces intestinal in¯ammation 11 and protein loss 12 and restores the intestinal mucosal barrier function. 13 However, despite its ef®cacy and lack of serious side-effects, elemental diet is not widely used for treatment of active Crohn's disease, partly because of its poor palatability, which in most cases requires enteral administration, and partly because of the considerable SUMMARY Background: Elemental diet is considered an effective primary treatment for active Crohn's disease, but it is usually given by a feeding tube. Methods: Twenty-two patients (12 males, median age 30 years, range 18±60) with moderately active Crohn's disease were enrolled in a randomized study in which the ef®cacy of an elemental diet administered orally was compared to high-dose corticosteroids in achieving clinical and laboratory remission.…”

Initial response and subsequent course of Crohn's disease treated with elemental diet or prednisolone.

“…The absence of whole excretion,6 1 ' and improve intestinal perme-protein or peptides in elemental diet effectively ability'5 16 This trial is the first to prospectively follow elemental diet or prednisolone induced remission in adult patients over a period of a year. Some of the patients assigned to prednisolone did receive this drug for more than four weeks.…”

Parallel Determination of Gut Permeability in Man with M r 400, M r 1500, M r 4000 and M r 10 000 Polyethylene Glycol

“…Until now, almost all the compounds · used to measure the intestinal permeability have been of Thus, intestinal permeability has been measured with low relative molecular mass (M T 180--M r 380). These either only low-Af r substances, or one containing radiohave been mannitol (1) and rhamnose (2), frequently in nuclides. A non-invasive test permitting the simultacomtynation with a disaccharide such s cellobiose (3, neous determination of human gut permeability to com-4) or lactulose (5)(6)(7).…”