Improvement of a commercial foot-and-mouth disease vaccine by supplement of Quil A

Xiao, Chi; Rajput, Zahid Iqbal; Hu, Songhua

doi:10.1016/j.vaccine.2007.04.027

Cited by 53 publications

(37 citation statements)

References 17 publications

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“…4). Although we did not carry out neutralizing studies, the serum antibody levels detected by the method described in this study parallel indirect hemagglutination titers, which were reported to be closely correlated with protection against FMDV infection (29). In comparison with 4 g of GS-R, 6 g of GS-R showed little adjuvant effect (Fig.…”

Section: Discussionsupporting

confidence: 57%

“…For example, Gerber reported that Quil A, in combination with oil as an adjuvant, promoted greater immune responses in pigs immunized against pseudorabies virus, in guinea pigs immunized against canine parvovirus, and in cats immunized against feline infectious virus (33), Martinez-Fernandez et al found that an oil emulsion containing Quil A increased the immune responses induced by Fh12 fatty acid-binding protein of Fasciola hepatica in sheep (34), and Xiao et al observed that supplements of saponins such as Quil A and extract from the seeds of Momordica cochinchinensis (Lour.) Spreng in FMD vaccines significantly enhanced immune responses in pigs (29,35). The synergism between RO and GS-R may be explained by the depot effect of oil emulsion, which slowly releases antigens at the injection site in combination with the immunostimulating effect created by GS-R. Figure 3 showed that serum IgG levels progressively declined but RO/GS-R reduced the rate of the decline.…”

Section: Discussionmentioning

confidence: 98%

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Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine

Zhang

Wang

et al. 2014

Clin. Vaccine Immunol.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine

Zhang

Wang

et al. 2014

Clin. Vaccine Immunol.

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“…This adjuvant was shown previously to increase antibody responses to several inactivated-virus vaccines (67,86). Quil A also tends to promote Th1 responses, whereas alum biases responses toward Th2 (73).…”

Section: Discussionmentioning

confidence: 84%

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Gardner

Anraku

et al. 2010

J Virol

376

661

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Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-␣), and gamma interferon (IFN-␥). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 g of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-␣ treatment was able to prevent arthritis only if given before infection, suggesting that IFN-␣ is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.

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“…Studies with animal models (McCullough et al, 1986(McCullough et al, , 1988 have shown that specific antibodies play an important role in the immune defense against FMD virus. However, poor humoral immune responses to FMD vaccination, in laboratory animals and pigs, have been reported previously (Shi et al, 2007;Xiao et al, 2007b). Fig.…”

Section: Short Communication Immune Responses Of Orally Administeredmentioning

confidence: 75%

Short communication. Enhancement of the immune responses to vaccination against foot-and-mouth disease in mice by oral administration of Quillaja saponaria-A and extracts of Cochinchina momordica seed

Xiao

Rajput

Bao

et al. 2013

Span. j. agric. res.

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This study was designed to evaluate the effects of oral administration of extracts from Cochinchina momordica seed (ECMS) or Quillaja saponaria-A (Quil-A) on the immune responses in mice immunized with foot and mouth disease virus (FMDV)-serotype O vaccine. Forty-two imprinting control region (ICR) mice were randomly divided into seven groups of 6 animals in each group, and a dose of 400 µg of Quil-A or ECMS was orally administered for 1, 2 or 3 days. After that, the animals were subcutaneously immunized twice with FMD vaccine at 3-week intervals and blood samples were collected 2-weeks after boosting for measurement of FMDV-specific IgG and its subclasses. Spleens were collected for lymphocytes proliferation assay. Results indicated that serum FMDV-specific IgG and the IgG subclass responses were significantly enhanced in mice orally administered ECMS or Quil-A when compared with the control group (p < 0.05). Lymphocytes proliferation response to FMD vaccine was significantly enhanced by ECMS compared with the control (p < 0.05). This study illustrates that ECMS induced immunomodulatory effects and performed better than Quil-A.

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Improvement of a commercial foot-and-mouth disease vaccine by supplement of Quil A

Cited by 53 publications

References 17 publications

Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine

Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine

Chikungunya Virus Arthritis in Adult Wild-Type Mice

Short communication. Enhancement of the immune responses to vaccination against foot-and-mouth disease in mice by oral administration of Quillaja saponaria-A and extracts of Cochinchina momordica seed

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