Improvement in the stability and bioavailability of pumpkin lutein using β‐cyclodextrin microcapsules

Abstract

Growing concerns about food nutrition and food supplies have encouraged the development of effective constituents. Lutein is an important nutrient element, and its health benefits are gradually being recognized. Lutein, as a carotenoid antioxidant, can protect cells and organs from damage caused by free radicals. However, in processing, storage, and usage, lutein is unstable and often undergoes isomerization and oxidative decomposition, which limits its wide range of applications. β‐Cyclodextrin is an ideal substrate to prepare microcapsule structures, which are highly biocompatible and nontoxic. During the lutein encapsulation process, ideal β‐cyclodextrin microcapsules were used to form inclusion compounds. The results reveal that the encapsulation efficiency of the microcapsules reached 53%. Moreover, using ultrasonic‐assisted extraction can easily and efficiently purify lutein. In addition, the capability of the β‐cyclodextrin composite shell can enhance the bioactive molecules' activity and stability.

Active and Intelligent Packaging: A Review of the Possible Application of Cyclodextrins in Food Storage and Safety Indicators

“…Lastly, the solution is filtered and dried to include complex powder [18,40]. To mention some studies with this methodology, we can highlight the preparation of a container based on lutein and β-CD with possible applications as IP or AP [67].…”

“…With the help of CDs, this damage can be slowed down, encasing it in its interior cavity. In another study, a possible application of an AP based on β-CD and lutein was performed, where the encapsulated lutein was guaranteed to protect its antioxidant properties [67]. Other plant pigments, like carotenoids, are flavonoids with antioxidant activity.…”

Clinical rationale for dietary lutein supplementation in post COVID-19 and mRNA vaccine injury syndromes

“…Therefore, technical advances on microencapsulation are being developed to solve these problems. 122 However, clinical studies on age-related macular degeneration (AMD) recommend that the consumption of food-based lutein is the best option, as the administration of supplements for AMD have given contradictory results. 123 This may be because high-dose administration of a single xanthophyl-carotenoid like lutein has the effect of altering the plasma and other tissue concentrations of other xanthophylls such as zeaxanthin, and carotenoids such as β-carotene, which are also beneficial for the prevention of human disease.…”

“…Regarding the food matrix and other dietary components that affect its stability, 122 the Lakshminarayana and colleagues animal study has found that olive oil (OO) is the optimum "carrier source" to achieve the best postprandial plasma concentrations of lutein that can reach the eyes. 24 In this study, the absorption of lutein did not affect the content of other carotenoids in animals.…”

Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and mRNA Vaccine Injury Syndromes

“…The food processing (heat, pH etc) that degrades the structural stability of lutein makes its bioavailability even worse. Therefore, technical advances on microencapsulation are being developed to solve these problems [122]. However, clinical studies on age-related macular degeneration (AMD) recommend that the consumption of food-based lutein is the best option, as the administration of supplements for AMD have given contradictory results [123].…”