Improvement in the Histopathology of Hearts from Cardiomyopathic BIO TO-2 Hamsters Following Long-Term Administration of Amlodipine and Cilnidipine.

Urayama, Akihiko; Yamada, Shizuo; Hirano, Kazufumi; Kimura, Ryohei; Watanabe, Hiroshi; Ohashi, Kyoichi

doi:10.1248/bpb.23.1189

Cited by 3 publications

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“…Thus it is possible that cilnidipine has some myocardial effects at dosages exhibiting hypotensive effects. Urayama et al 18) have shown that long-term administration of cilnidipine improved calcium deposition and necrosis in the myocardium from dilated cardiomyopathic hamsters. Furthermore, no consistent reduction in (ϩ)-[ 19) and Uchida et al, 20) who showed that nifedipine could easily cross the blood-brain barrier in rats.…”

Section: Specific Binding Of (ϩ)-[mentioning

confidence: 99%

In Vivo Measurement of 1,4-Dihydropyridine Receptors in Mesenteric Arteries of Spontaneously Hypertensive Rats and Effect of Nifedipine and Cilnidipine.

Nakajima

Yamada

Uchida

et al. 2002

Biological & Pharmaceutical Bulletin

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The present study was undertaken to measure 1,4-dihydropyridine (DHP) receptor binding sites in vivo in the mesenteric artery and other tissues of spontaneously hypertensive rats (SHR) and to examine the effect of nifedipine and cilnidipine. Specific in vivo binding of (؉)- 4 or 1.7) of the AUC mesenteric artery to AUC aorta or AUC myocardium after oral administration of cilnidipine was greater than the corresponding value (1.1) for nifedipine. In conclusion, the present study demonstrates that cilnidipine, but not nifedipine, may occupy 1,4-DHP receptors in the small artery in a more selective and sustained manner than in other tissues of SHR, and thus such receptor binding specificity may be responsible for the long-lasting hypotensive effect of this drug.

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Section: Specific Binding Of (ϩ)-[mentioning

confidence: 99%

In Vivo Measurement of 1,4-Dihydropyridine Receptors in Mesenteric Arteries of Spontaneously Hypertensive Rats and Effect of Nifedipine and Cilnidipine.

Nakajima

Yamada

Uchida

et al. 2002

Biological & Pharmaceutical Bulletin

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Application of oxidants to the spectrophotometric determination of amlodipine besylate in pharmaceutical formulations

2004

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Three new spectrophotometric methods for the determination of amlodipine besylate have been proposed. The first two methods, i.e. A and B, are based on the oxidation of the drug with Fe(III) and the estimation of Fe(II) produced after chelation with either 1,10-phenanthroline or 2,2'-bipyridyl at 500 and 515 nm, respectively. The Beer's law was obeyed in the concentration ranges of 2-10 and 4-14 microg ml(-1) with molar absorptivity of 2.9 x 10(4) and 2.7 x 10(4) l mol(-1) cm(-1) for methods A and B, respectively. The third procedure depends on the interaction of amlodipine besylate with ammonium heptamolybdate tetrahydrate, which resulted in the formation of molybdenum blue (lambda(max) 825 nm). The linear dynamic range and the molar absorptivity values were found to be 15-59 microg ml(-1) and 1.8 x 10(4) l mol(-1) cm(-1), respectively. The results of the proposed procedures were validated statistically and compared with those obtained by the reference method. The proposed methods were applied successfully to the determination of amlodipine besylate in commercial tablets.

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Validated spectrophotometric methods for the determination of amlodipine besylate in drug formulations using 2,3-dichloro 5,6-dicyano 1,4-benzoquinone and ascorbic acid

Rahman

Hoda

2003

Journal of Pharmaceutical and Biomedical Analysis

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Improvement in the Histopathology of Hearts from Cardiomyopathic BIO TO-2 Hamsters Following Long-Term Administration of Amlodipine and Cilnidipine.

Cited by 3 publications

References 0 publications

In Vivo Measurement of 1,4-Dihydropyridine Receptors in Mesenteric Arteries of Spontaneously Hypertensive Rats and Effect of Nifedipine and Cilnidipine.

In Vivo Measurement of 1,4-Dihydropyridine Receptors in Mesenteric Arteries of Spontaneously Hypertensive Rats and Effect of Nifedipine and Cilnidipine.

Application of oxidants to the spectrophotometric determination of amlodipine besylate in pharmaceutical formulations

Validated spectrophotometric methods for the determination of amlodipine besylate in drug formulations using 2,3-dichloro 5,6-dicyano 1,4-benzoquinone and ascorbic acid

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