Improvement in Quality‐of‐Life Measures and Stimulation of Weight Gain After Treatment with Megestrol Acetate Oral Suspension in Geriatric Cachexia: Results of a Double‐Blind, Placebo‐Controlled Study

Yeh, Shing-Shing; Wu, Suh‐Yuh; Lee, Tai-Ping; Olson, Jeffery S.; Stevens, Michael R.; Dixon, Troy E.; Schuster, Michael W.

doi:10.1111/j.1532-5415.2000.tb04993.x

Cited by 140 publications

(118 citation statements)

References 36 publications

(34 reference statements)

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“…[14][15][16][21][22][23][24][25][26][27] All four trials were small and only one was a blinded randomized control trial. [23][24][25][26][27] The most commonly studied medication was megestrol acetate. One study also looked at the use of dronabinol for unexplained weight loss.…”

Section: Pharmacologic Treatmentmentioning

confidence: 99%

“…[23][24][25][26][27] Sixtynine patients were randomly assigned to receive placebo or megestrol 800 mg/d for 12 weeks. At 12 weeks, there were no significant differences in weight gain between treatment groups, although patients treated with megestrol reported significantly greater improvements in appetite, enjoyment of life and well-being.…”

Section: Pharmacologic Treatmentmentioning

confidence: 99%

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Unintentional weight loss in older adults

Stajkovic¹,

Aitken²,

Holroyd‐Leduc³

2011

Canadian Medical Association Journal

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A 73-year-old woman presents to your clinic complaining of unintentional weight loss. She reports having lost 15 lbs (6.8 kg) over the past year. Previously, her weight was 135 lbs (61.3 kg) and now it is 120 lbs (54.5 kg). She reports that she is eating three meals per day as usual.The patient's past medical history is notable for osteoporosis, a left hip fracture three years ago, osteoarthritis, hypothyroidism and hypercholesterolemia. She is taking levothyroxine, a statin and a bisphosphonate plus vitamin D and calcium. She recently started taking nonsteroidal anti-inflammatory medications (NSAIDs) as needed for knee pain. She is an exsmoker and does not drink alcohol. On examin ation, her weight was 121 lbs (55 kg), with a body mass index (BMI) of 22. She also had osteoarthritic changes in the knees. Results of investigations, including radiograph of the chest, complete blood count, electrolytes, creatinine, thyroid stimulating hormone and albumin are within normal limits.

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Section: Pharmacologic Treatmentmentioning

confidence: 99%

Section: Pharmacologic Treatmentmentioning

confidence: 99%

Unintentional weight loss in older adults

Stajkovic¹,

Aitken²,

Holroyd‐Leduc³

2011

Canadian Medical Association Journal

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“…90,91 Evidence for its use with elderly people is limited. 89,[91][92][93] Ornithine oxoglutarate led to weight gain in one randomized trial but has not been studied in other trials. 86 There are no randomized trials of either cyproheptadine or dronabinol in elderly people with weight loss, although dronabinol has been studied in one trial involving patients with dementia who were refusing food.…”

Section: Pharmacologic Therapy To Reverse Weight Lossmentioning

confidence: 99%

An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

228

143

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UNINTENTIONAL WEIGHT LOSS, or the involuntary decline in total body weight over time, is common among elderly people who live at home. Weight loss in elderly people can have a deleterious effect on the ability to function and on quality of life and is associated with an increase in mortality over a 12-month period. A variety of physical, psychological and social conditions, along with age-related changes, can lead to weight loss, but there may be no identifiable cause in up to one-quarter of patients. We review the incidence and prevalence of weight loss in elderly patients, its impact on morbidity and mortality, the common causes of unintentional weight loss and a clinical approach to diagnosis. Screening tools to detect malnutrition are highlighted, and nonpharmacologic and pharmacologic strategies to minimize or reverse weight loss in older adults are discussed.

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“…However, in one study 50 depleted American nursing-home residents (mean age 76 years) were randomized to megestrol acetate treatment for 12 weeks. Together with improved appetite and small effects on weight, the patients reported a better sense of well-being (17).…”

Section: Macronutrient or Micronutrient Deficiency?mentioning

confidence: 95%

Psychological effects of generalized nutritional deprivation in the elderly

Cederholm¹

2003

Food & Nutrition Research

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The Minnesota starvation study from the mid 1940s provides convincing evidence that imposed nutritional deprivation and weight loss induce depression, irritability and asociability. Similar findings are recently reported in elderly institutionalized and home-living malnourished populations, although confounding effects of concurring disease cannot be excluded. Several key nutrients influence mood, e.g. carbohydrates, tryptophane, vitamin B 12 , folate, thiamine and iron, and it is reasonable to believe that the detrimental psychological effects of generalized malnutrition are a combined effect of such key nutrient deficiencies. The few nutrition intervention studies in malnourished elderly, using a balanced nutrient supply, report conflicting data on psychological effects.

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Improvement in Quality‐of‐Life Measures and Stimulation of Weight Gain After Treatment with Megestrol Acetate Oral Suspension in Geriatric Cachexia: Results of a Double‐Blind, Placebo‐Controlled Study

Cited by 140 publications

References 36 publications

Unintentional weight loss in older adults

Unintentional weight loss in older adults

An approach to the management of unintentional weight loss in elderly people

Psychological effects of generalized nutritional deprivation in the elderly

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