Improvement in quality of life and pain scores after laparoscopic management of deep endometriosis: a retrospective cohort study

Baştu, Ercan; Çelik, Hale Göksever; Kocyigit, Yucel; Yozgatli, Dilara; Yaşa, Cenk; Ozaltin, Selin; Tas, Inci Sema; Soylu, Meryem; Durbas, Atahan; Görgen, Hüsnü; Buyru, Faruk

doi:10.1007/s00404-020-05583-6

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Parra et al showed that half of patients with deep in ltrative endometriosis and rectosigmoid invasion who underwent laparoscopic surgery had reduced pelvic pain, increased daily activity performance, and had better work performance [20]. In a retrospective study, health care providers observed that dysmenorrhea, dyspareunia, and CPP complaints decreased by the three-month postoperative evaluation in patients with deep in ltrative endometriosis [21]. Likewise, in another study comparing de nitive surgery and uterine-sparing laparoscopic excision in the treatment of endometriosis, it was observed that there was an improvement in the quality of life in both groups postoperatively [22].…”

Section: Endometriosis and Quality Of Lifementioning

confidence: 99%

Analysis of preoperative and postoperative quality of life, sexual function, and sleep in patients with endometriosis: a prospective cohort study

Halıcı

Aktoz

Kabakci

et al. 2022

Arch Gynecol Obstet

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Endometriosis affects the quality of life, sleep, and sexual life of patients due to pain. This study compared the scores of endometriosis patients in these three areas before and after surgery. MethodsPatients between the ages of 18-60 with a prediagnosis of endometriosis were enrolled. Postoperative histopathological diagnosis of endometriosis was con rmed in all patients. This study included 56 patients who completed pre-and postoperative (three months) evaluation of quality scale questionnaires: a visual analog scale for pelvic pain, the Pittsburgh Sleep Quality Index, Morningness-Eveningness Questionnaire, Endometriosis Health Pro le-30 Questionnaire, and Female Sexual Function Index were administered prior to and three months after each patient's surgery. ResultsAmong the 56 female patients included in this study, statistically signi cant improvement statistically signi cant improvement was observed in pain scores, quality of life, sexual function, and sleep of all patients regardless of endometriosis stage. ConclusionEndometriosis is a disease that progresses, with increasing pain scores; it has negative effects on the quality of life, sexual function, and sleep of patients. Surgical or medical treatment can be performed considering the complaints and fertility status of the patients.

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Section: Endometriosis and Quality Of Lifementioning

confidence: 99%

Analysis of preoperative and postoperative quality of life, sexual function, and sleep in patients with endometriosis: a prospective cohort study

Halıcı

Aktoz

Kabakci

et al. 2022

Arch Gynecol Obstet

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“…Current surgical procedures and medical treatments for endometriosis are ineffective for the majority of women. Even if the treatments are effective, it is often accompanied by severe complications and a high recurrence rate [ 19 ]. Moreover, hormone therapy is not suitable for women with endometriosis who intend to have children [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression and Bioinformatics Analysis of tRF/tiRNA in Endometriosis Patients

Wangshu¹,

Li²,

Cao³

et al. 2022

BioMed Research International

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Background. Endometriosis (EMs) is a benign chronic condition that tends to recur in women of childbearing age, with an incidence of approximately 10%. It is a multifactorial disease for which the pathogenesis is currently unclear. This study is aimed at investigating the expression and clinical significance of tRNA-derived small RNA (tsRNA), a novel noncoding small RNA with potential regulatory functions, in endometriosis. Methods. The tRF/tiRNA expression profiles in endometrial tissues from three pairs of endometriosis patients and controls were detected by tRF&tiRNA PCR microarray technology and then verified by quantitative real-time polymerase chain reaction (qPCR). The target genes and target sites of TRF396, tiRNA-5030-GlnTTG-3, TRF308, and TRF320 were predicted by miRanda, and the network diagram of their interaction with miRNA was drawn. The impact of tRNA-derived fragments on the pathogenesis of endometriosis was analyzed using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Results. Two upregulated and 19 downregulated tRNA-derived fragments were identified. The qRT-PCR results of 2 upregulated and 2 downregulated RNA-derived fragments were consistent with the RNA Seq data. The OR2B4 gene related to TRF396, the DGAT1 gene related to tiRNA-5030-GlnTTG-3, the KLF16 gene of TRF308, and the RNF213 gene of TRF320 had significant correlations. Gene Ontology and pathway analysis showed that the target genes of TRF396 and tiRNA-5030-GlnTTG-3 were mainly involved in the intrinsic components of the membrane and the overall composition of the membrane in cell components; molecular functions mainly involve olfactory conduction and G protein-coupled receptor activity. In the biological process, it was mainly involved in the detection of sensory stimuli. The target genes of TRF308 and TRF320 were mainly involved in the intracellular part; molecular functions are mainly related to DNA binding transcription factor activity and protein binding and mainly related to biological regulation of biological processes. Pathway analysis showed that the RAP1 signaling pathway and the AXON GUIDANCE signaling pathway may participate in the progression of endometriosis. Conclusion. The differential expression of tRF/tiRNA in endometriosis may be related to the pathogenesis of endometriosis. Furthermore, tRF/tiRNA may be a biomarker for the diagnosis and treatment of EMs in the future.

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“…It is well established that general QOL can be severely impaired in patients with DE 17–19 . Recent cross‐sectional and retrospective cohort studies of 77 and 65 patients each, have reported an improved QOL after surgery for DE 20,21 . The ICIQ‐B questionnaire allowed us to specifically address the impact LGF has on QOL.…”

Section: Discussionmentioning

confidence: 99%

Lower gastrointestinal function after surgery for deep endometriosis: A prospective cohort study

Dior

Reddington

Cheng

et al. 2022

Intl J Gynecology & Obste

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Endometriosis, estimated to affect 10% of reproductive aged women, 1 is an under-recognized cause of gastrointestinal symptoms. 2 Endometriosis-associated gastrointestinal symptoms include abdominal pain, cyclical rectal bleeding, cyclical dyschezia, pain with a full bowel, abdominal bloating, constipation, and diarrhea. 3 Deep endometriosis (DE), considered to be the most severe form of endometriosis, describes infiltrative forms of the disease and may involve any pelvic or abdominal structure. DE may infiltrate the colon directly or effect it indirectly, such as when the pouch of Douglas is obliterated. As such, DE is very commonly staged as stage 4 disease, 4 as per the revised American Society for Reproductive Medicine (rASRM) endometriosis scoring system. 5 Even without

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Improvement in quality of life and pain scores after laparoscopic management of deep endometriosis: a retrospective cohort study

Cited by 9 publications

References 28 publications

Analysis of preoperative and postoperative quality of life, sexual function, and sleep in patients with endometriosis: a prospective cohort study

Analysis of preoperative and postoperative quality of life, sexual function, and sleep in patients with endometriosis: a prospective cohort study

Differential Expression and Bioinformatics Analysis of tRF/tiRNA in Endometriosis Patients

Lower gastrointestinal function after surgery for deep endometriosis: A prospective cohort study

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