Improvement in Physical Activity in Persons With Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure

Jean, Raymonde; Duttuluri, Manideep; Gibson, Charlisa D.; Mir, Sadaf; Eden, Edward; Supariwala, Azhar

doi:10.1123/jpah.2016-0289

Cited by 19 publications

(22 citation statements)

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“…Three studies utilised subjective, questionnaire-based measures of physical activity [47, 69, 70], and 12 studies [34, 38, 48, 49, 71–78], including three conference abstracts [72, 73, 75], assessed physical activity using objective measures.…”

Section: Resultsmentioning

confidence: 99%

“…However, these preliminary findings, which are based on small sample sizes and are less fully described, should be expanded upon. Another conference abstract described a significantly increased number of pedometer-recorded steps per day in 62 participants with at least mild OSA after CPAP for 3 and 7 months compared to baseline [72]. …”

Section: Resultsmentioning

confidence: 99%

“…Some have described an effect of CPAP on improving objectively measured physical activity outcomes, including steps per day [71, 72]. Overall, however, it appears that CPAP has minimal effects on improving free-living physical activity levels.…”

Section: Discussionmentioning

confidence: 99%

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Effects of continuous positive airway pressure on energy balance regulation: a systematic review

Shechter

2016

Eur Respir J

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Obesity is both a cause and a possible consequence of obstructive sleep apnoea (OSA), as OSA seems to affect parameters involved in energy balance regulation, including food intake, hormonal regulation of hunger/satiety, energy metabolism and physical activity. It is known that weight loss improves OSA, yet it remains unclear why continuous positive airway pressure (CPAP) often results in weight gain. The goal of this systematic review is to explore if and how CPAP affects the behaviour and/or metabolism involved in regulating energy balance. CPAP appears to correct for a hormonal profile characterised by abnormally high leptin and ghrelin levels in OSA, by reducing the circulating levels of each. This is expected to reduce excess food intake. However, reliable measures of food intake are lacking, and not yet sufficient to make conclusions. Although studies are limited and inconsistent, CPAP may alter energy metabolism, with reports of reductions in resting metabolic rate or sleeping metabolic rate. CPAP appears to not have an appreciable effect on altering physical activity levels. More work is needed to characterise how CPAP affects energy balance regulation. It is clear that promoting CPAP in conjunction with other weight loss approaches should be used to encourage optimal outcomes in OSA patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of continuous positive airway pressure on energy balance regulation: a systematic review

Shechter

2016

Eur Respir J

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“…OSAHS therapies include behavioral treatment 14 , continuous positive airway pressure (CPAP) treatment 15,16 , mandibular advancement devices (MADs) 17,18 , and surgeries to enlarge the upper airway, such as uvulopalatopharyngoplasty (UPPP) and maxilla-mandibular advancement osteotomy 19 . It is popular to use MADs for most OSAHS patients, especially those unable to tolerate CPAP therapy, due to their many advantages, such as being traumatic, convenient, and low cost.…”

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confidence: 99%

Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)

Liu

Kang

Zhang

et al. 2020

Sci Rep

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Although considerable research highlights the interactions between obstructive sleep apnea-hypopnea syndrome (OSAHS) and cardiovascular diseases, the effect of mandibular advancement device (MAD) treatment on cardiovascular complications in OSAHS patients remains unclear. We evaluated the effect of OSAHS treatment with MADs on the myocardium. All methods in this study were in accordance with relevant guidelines and regulations of the medical ethics committee in Hospital of Stomatology, Hebei Medical University approved the work. Thirty New Zealand rabbits were randomized into three groups: the control group, Group OSAHS, and Group MAD. Hydrophilic polyacrylamide gel was injected into the soft palate of the rabbits to induce OSAHS. In Group MAD, a MAD was positioned after OSAHS induction. All animals were induced to sleep in a supine position for 4-6 h/day for 8 weeks. Echocardiography was used to determine the structure and function of the heart. The histological changes were detected by optical microscopy and transmission electron microscopy (TEM). The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma were measured by an enzyme-linked immunosorbent assay (ELISA). The expression of ET-1 mRNA in heart tissue was detected by RT-PCR. Histological abnormalities, left ventricular hypertrophy, and left ventricular dysfunctions were demonstrated in Group OSAHS, and the abnormities were rescued with MAD treatment. Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS compared with Group MAD and the control group. The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II. OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structural abnormalities and dysfunction. Early treatment of MADs may play an important role in preventing myocardial damage in OSAHS rabbit model.

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“…Additionally, fatigue is a common symptom of OSA, resulting in the limitation of physical activity and/or poor quality of life [19]. Regular CPAP use may increase the amount of physical activity in which a patient engages by 1431 steps•day −1 over 7 months and may improve sleep quality ( p<0.001) [20]. Therefore, patients with OSA who had fatigue tended to have good CPAP compliance.…”

Section: Discussionmentioning

confidence: 99%

Are symptoms of obstructive sleep apnoea related to good continuous positive airway pressure compliance?

2020

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Obstructive sleep apnoea (OSA) is a common disease that can be treated with continuous positive airway pressure (CPAP). CPAP tolerance may be associated with its compliance. Even though there are several predictors for good CPAP compliance, there are limited data available on the correlation between CPAP compliance and OSA symptoms. This study aimed to evaluate this correlation. We conducted a cross-sectional study and enrolled adult patients diagnosed with OSA through polysomnography who had experience using a CPAP machine. A self-report questionnaire was used to evaluate CPAP compliance and study variables. Predictors of CPAP compliance were analysed using stepwise multivariate logistic regression analysis. There were 68 patients with OSA who completed the questionnaire during the study period. Of those, 14 (20.59%) exhibited good CPAP compliance. Only fatigue as a symptom was an independent factor associated with good CPAP compliance, with an adjusted odds ratio of 5.380 (95% CI 1.274–22.719). In conclusion, fatigue was the only symptom associated with good CPAP compliance in patients with OSA.

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Improvement in Physical Activity in Persons With Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure

Abstract: Treatment of OSA with CPAP had a progressive incremental improvement in sleep quality and actual PA.

Cited by 19 publications

References 0 publications

Effects of continuous positive airway pressure on energy balance regulation: a systematic review

Effects of continuous positive airway pressure on energy balance regulation: a systematic review

Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)

Are symptoms of obstructive sleep apnoea related to good continuous positive airway pressure compliance?

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