Improvement in natamycin production by Streptomyces natalensis with the addition of short-chain carboxylic acids

Structural modifications and yield improvements of polyene macrolide antibiotics

“…多烯大环内酯抗 生素属于I型聚酮化合物, 主要以丙二酰CoA或甲基 丙二酰CoA为前体完成聚酮骨架组装 [34] . 此外, 链霉 [85] 或以7 : 1比例添加2 g/L乙酸与丙酸 [86] , 可以使匹马霉素的产量分别提高17%或2.5倍. 除增 加前体供给外, 还可以通过抑制或中断竞争途径提 高多烯大环内酯抗生素的产量.…”

Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale

“…The concentration of OTC was quantitatively determined using agar plate diffusion method (Farid et al 1994a,b;Elsayed et al 2013). The diameter of inhibition zone was converted to OTC mg/L using a biological standard curve between the logarithm of different antibiotic concentrations and the mean diameters of the inhibition zone of B. subtilis NRRL-B543.…”

“…Carbon source limitation in actinomycetes can cause either degradation of the produced antibiotic or decrease in biomass production depending on the structure and the stability of the product. If cells can degrade the product and use it for energy maintenance, the cells will survive without lysis phase (Elsayed et al 2013). Whereas, if the product is stable and could not be used as source of energy maintenance, cells will lyse accordingly.…”

Determination of Natamycin in Fermented Dry Salami Casings

“…The substance is produced by some Streptomyces natalensis and Streptococcus lactis bacteria (Elsayed et al . ). In the amounts of 5–10 mg/kg, it can kill fungi and yeasts; nevertheless, natamycin is not effective against bacteria (Velíšek ).…”