Improvement in Long-Term Memory following Chronic Administration of<i>Eryngium planum</i>Root Extract in Scopolamine Model: Behavioral and Molecular Study

Ożarowski, Marcin; Thiem, Barbara; Mikołajczak, Przemysław Ł.; Piasecka, Anna; Kachlicki, P.; Szulc, Michał; Kamińska, Ewa; Bogacz, Anna; Kujawski, Radosław; Bartkowiak‐Wieczorek, Joanna; Kujawska, Małgorzata; Jodynis‐Liebert, Jadwiga; Budzianowski, Jaromir; Kędziora, Izabela; Seremak‐Mrozikiewicz, Agnieszka; Czerny, Bogusław; Bobkiewicz-Kozlowska, T.

doi:10.1155/2015/145140

Cited by 20 publications

(11 citation statements)

References 55 publications

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“…− ) was found in the MS/MS spectrum of compound 64 and corresponded with the tetrahydroxyflavone moiety.Several triterpenoid saponins were found in the samples. Similar to Ożarowski et al[17], we observed precursors and the fragmentation pattern as in the related species, E. planum. The pseudo-molecular ion at m/z 471.34903 corresponded with the molecular formula C 30 H 47 O 4 E. planum and E. maritimum[22].…”

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confidence: 90%

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

et al. 2020

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Genetically uniform shoots of Eryngium alpinum L. cultured in vitro were subjected to the qualitative analysis applying the UPLC-HESI-HRMS technique. In vitro cultures give the opportunity to perform the phytochemical studies on the protected species without harvesting the plant material from the natural environment. The phytochemical screening of the crude methanolic extracts of shoots, both from in vitro cultures and in vivo plants, revealed the presence of phenolic acids, coumarins, flavonoids, triterpenoid saponins, amino acids, or dipeptides. Active compounds detected are known to have medicinal importance, and for this reason, the present study represents a preliminary investigation of the extracts against pathogenic and opportunistic amoeba. Among the extracts tested, the extract of shoots from in vitro cultures exhibited remarkable amoebicidal action against trophozoites. On the second day of treatment, the extract at the concentrations of 5 mg/mL, 2.5 mg/mL, and 0.5 mg/mL showed the highest antiamoebicidal effect: the inhibition of trophozoites reached 81.14%, 66.38%, and 54.99%, respectively. To our best knowledge, the present report is the first to show the phytochemical screening and to discuss the antiamoebic activity of Eryngium alpinum L. shoots, both from in vitro cultures and in vivo plants.

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confidence: 90%

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

et al. 2020

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“…[ 24 – 27 , 43 – 45 ]. A large scale of evidence has pointed out to multiple pharmacological effects of the genus Eryngium species including antioxidant, anti-inflammatory, antihemolytic, antinociceptive effects, and protective agent against neurodegenerative deseases [ 25 , 28 , 48 – 50 ]. For instance, Eryngium planum , which is a rare medicinal plant, was studied to determine the effect of subchronic administration of a 70 % ethanol root extract (200 mg/kg, p.o.)…”

Section: Methodsmentioning

confidence: 99%

“…At the end of the experiment, after the last dose of the Eryngium extract, scopolamine (SC) was administered intraperitoneally to a group of animals (treated). In the animals treated with the Eryngium extract, an improvement in long-term memory produced by the EP extract in both scopolamine treated and control group was registered with decreased mRNA AChE, BuChE, and BACE-1 levels, especially in the frontal cortex, suggesting the potential efficacy of this extract in this kind of pathologies [ 25 , 28 , 48 – 50 ].…”

Section: Methodsmentioning

confidence: 99%

Blessings in disguise: a review of phytochemical composition and antimicrobial activity of plants belonging to the genus Eryngium

et al. 2015

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Medicinal and edible plants play a crucial role in the prevention and/or mitigation of different human diseases from ancient times to today. In folk medicine, there are different plants used for infectious disease treatment. During the past two decades, much attention has been paid to plants as novel alternative therapeutic agents for the treatment of infectious diseases due to their bioactive natural compounds such as phenol, flavonoids, tannins, etc. The genus Eryngium (Apiaceae) contains more than 250 flowering plant species, which are commonly used as edible and medicinal plants in different countries. In fact, some genus Eryngium species are used as spices and are cultivated throughout the world and others species are used for the treatment of hypertension, gastrointestinal problems, asthma, burns, fevers, diarrhea, malaria, etc. Phytochemical analysis has shown that genus Eryngium species are a rich source of flavonoids, tannins, saponins, and triterpenoids. Moreover, eryngial, one the most important and major compounds of genus Eryngium plant essential oil, possesses a significant antibacterial effect. Thus, the objective of this review is to critically review the scientific literature on the phytochemical composition and antibacterial effects of the genus Eryngium plants. In addition, we provide some information about traditional uses, cultivation, as well as phytochemistry.

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“…Although sometimes a lack of correlation between the results at the formation of the protein and transcriptional occurs and reflects the complex interaction at the level of transcription and translation of particular substance of natural origin ( Ożarowski et al, 2013 , 2015 ; Mikołajczak et al, 2015 ), clearly establish the profile of anti-inflammatory OAO-ASA (8) and the mechanisms responsible for this is not possible on the basis of the obtained results.…”

Section: Discussionmentioning

confidence: 90%

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

et al. 2016

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The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3–300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw edema in rats for the same range of doses. The conjugate OAO-ASA (8) did not significantly change locomotor activity of mice, therefore sedative properties of the compound should be excluded. The compound 8 proved a simple, proportional, dose-dependent analgesic action and expressed strong anti-inflammatory activity showing a reversed U-shaped, dose-dependent relation with its maximum at 30.0 mg/kg. After its combined administration with morphine (MF, 5.0 mg/kg, s.c.) the lowering of antinociceptive activity was found; however, the interaction with naloxone (NL, 3.0 mg/kg, s.c.) did not affect the antinociceptive effect of OAO-ASA (8), therefore its opioid mechanism of action should be rather excluded. After combined administration with acetylsalicylic acid (ASA, 300.0 mg/kg, p.o.) in hot-plate test, the examined compound 8 enhanced the antinociceptive activity in significant way. It also shows that rather the whole molecule is responsible for the antinociceptive and anti-inflammatory effect of the tested compound 8, however, it cannot be excluded that the summarizing effect is produced by ASA released from the compound 8 and the rest of triterpene derivative. The occurrence of tolerance for triterpenic derivative 8 was not observed, since the analgesic and anti-inflammatory effects after chronic administration of the conjugate OAO-ASA (8) was on the same level as after its single treatment. It seemed that the anti-inflammatory mechanism of action of OAO-ASA (8) is not simple, even its chronic administration lowered both blood concentration of IL-6 and mRNA IL-6 expression. However, the effects of the conjugate OAO-ASA (8) on TNF-α level and mRNA expression were opposite. Moreover, compound 8 did not change unequivocally mRNA TLR1, and TLR3 expression. Concluding, the obtained results regarding the antinociceptive and anti-inflammatory activity of new conjugate of oleanolic acid oxime and acetylsalicylic acid (OAO-ASA 8) are very interesting, but for explanation of its mechanism of action, more detailed studies are necessary.

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Improvement in Long-Term Memory following Chronic Administration ofEryngium planumRoot Extract in Scopolamine Model: Behavioral and Molecular Study

Cited by 20 publications

References 55 publications

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

Blessings in disguise: a review of phytochemical composition and antimicrobial activity of plants belonging to the genus Eryngium

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

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