Improvement in Fetomaternal Outcomes and Cardiovascular Health in Gestational Diabetes Mellitus following a Short-course Yoga Therapy

Renugasundari, Manoharan; Pal, Gopal Krushna; Chaturvedula, Latha; Nanda, Nivedita; Harichandrakumar, K T; Vidyalakshmi, Lakshmanan

doi:10.5530/ijcep.2021.8.1.5

Cited by 2 publications

(2 citation statements)

References 15 publications

(19 reference statements)

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“…This is the first report of an RCT of twenty weeks practice of a structured yoga programme on fetomaternal-neonatal outcomes in pregnant women having risk of GH. Recently we have reported improvement of fetomaternal outcomes and CV health following a short-course yoga therapy consisting mainly of slow pranayamas and basic relaxing asanas in women having risk of developing gestational diabetes mellitus 35 . Though there are earlier reports of improvement in pregnancy outcomes by yoga in HDP 9 – 11 , the design and data analysis were different and cause-effect relationships have not been assessed in those studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial

Karthiga

Pal

Dasari

et al. 2022

Sci Rep

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Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. Though yoga is known to be beneficial in pregnancy, the effects of yoga rendered for twenty weeks starting from 16th week of gestation in pregnant women having risk of GH on the incidence of hypertension, cardiometabolic risks and fetomaternal outcomes have not been studied. A randomized control trial was conducted on 234 pregnant women having risk of GH receiving standard antenatal care (Control group, n = 113), and receiving standard care + yoga (Study group, n = 121). Interventions were given for twenty weeks starting at 16th week of gestation. Baroreflex sensitivity (BRS), heart rate variability (HRV), insulin resistance, lipid-risk factors, and markers of inflammation, oxidative stress and vascular endothelial dysfunction (VED) were assessed before and after intervention. Incidence of new-onset hypertension, level of cardiometabolic risks at 36th week, and fetomaternal-neonatal outcomes in the perinatal period, were noted. The link of hypertension, pregnancy outcomes and cardiometabolic risks with nitric oxide (NO), the marker of VED was assessed by analysis of covariance, Pearson’s correlations, and multilinear and logistic regressions. In study group, 6.61% women developed hypertension compared to 38.1% in the control group following 20-week intervention and there was significant decrease in risk of developing GH (RR, 2.65; CI 1.42–4.95). There was less-painful delivery, decreased duration of labor, increased neonatal birthweight and Apgar score in study group. Increase in total power of HRV (β = 0.187, p = 0.024), BRS (β = 0.305, p < 0.001), and decrease in interleukin-6 (β = − 0.194, p = 0.022) had significant association with increased NO. Twenty weeks of practice of yoga during pregnancy decreases the incidence of hypertension, improves fetomaternal outcomes, and reduces cardiometabolic risks in pregnant women having risk of GH. Decreased blood pressure, increased HRV, BRS and birth weight and decreased inflammation were associated with improved endothelial function. Trial registration: Clinical Trials Registry of India (CTRI), registration number: CTRI/2017/11/010608, on 23.11.2017.

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Section: Discussionmentioning

confidence: 99%

Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial

Karthiga

Pal

Dasari

et al. 2022

Sci Rep

Self Cite

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“…Women with history of GDM have a sevenfold increased risk of developing T2DM, with 20-70% risk in the first decade after delivery. [10] Therefore, GDM is an established clinical predictor of future risk of diabetes, and affected women are more than seven times more likely to have type 2 diabetes than women of their age. Many studies have shown that women with GDM have a higher incidence of cardiovascular events postpartum.…”

Section: Introductionmentioning

confidence: 99%

Cardiometabolic Risks in Gestational Diabetes Mellitus: A Mini-Review

Renugasundari

Pal

Chaturvedula

et al. 2022

Int. J. Clinical and Exp. Physiol.

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Diabetes is one of the most common medical problems encountered in about 3.8% -41% of pregnancies across the various parts of India. It contributes to maternal morbidity and mortality, especially in developing countries. Insulin resistance and β -cell dysfunction are the characteristics of GDM. Women with GDM had many immediate adverse fetomaternal and neonatal outcomes. In addition to the immediate adverse outcomes, women with GDM also had long-term complications such as dyslipidemia, metabolic syndrome, hypertension, type 2 diabetes, cardiovascular disease in later life. Current evidence suggests that GDM is highly associated with cardiometabolic risks (CMR) during gestation and in post-gestational period. Though the mechanism behind the pathogenesis of CMR in GDM is multifactorial, placental hormones, inflammation, endothelial dysfunction and oxidative stress play a significant role in the pathophysiology of cardiovascular risks in pregnant women with GDM.

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Improvement in Fetomaternal Outcomes and Cardiovascular Health in Gestational Diabetes Mellitus following a Short-course Yoga Therapy

Cited by 2 publications

References 15 publications

Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial

Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial

Cardiometabolic Risks in Gestational Diabetes Mellitus: A Mini-Review

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