Improvement in Exercise Capacity in Asymptomatic and Mildly Symptomatic Adults After Atrial Septal Defect Percutaneous Closure

Brochu, Marie-Claude; Baril, Jean‐François; Dore, Annie; Juneau, Martin; Guise, Pierre de; Mercier, Lise‐Andrée

doi:10.1161/01.cir.0000029924.90823.e0

Cited by 153 publications

(111 citation statements)

References 20 publications

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“…After repair of the ASD, exercise capacity improves within days to weeks. 11,12 Atrial arrhythmia, resulting from stretching of the conduction system, may be the first presenting sign of an ASD. An adult who presents with atrial arrhythmia at a young age should be evaluated for dilatation of the right-side cardiac chambers and evidence of an atrial level shunt.…”

Section: Natural Historymentioning

confidence: 99%

Pathophysiology of Congenital Heart Disease in the Adult

2008

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Section: Natural Historymentioning

confidence: 99%

Pathophysiology of Congenital Heart Disease in the Adult

2008

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“…Improvement in functional capacity following ASD closure was studied by Brochu et al (2002). Thirty-seven patients with a mean age of 49 years whose mean Qp:Qs was 2:1 were evaluated.…”

Section: Effect Of Asd Closure On Functional Capacitymentioning

confidence: 99%

Why, When and How Should Atrial Septal Defects Be Closed in Adults

Rao¹

2012

Atrial Septal Defect

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“…The indications for ASD closure in adults however are ambiguous. The most controversial issue is selection of candidates for ASD closure who have normal pulmonary artery pressure, absent or negligible clinical symptoms and are over 40 years of age [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Plasma Endothelin-1 in patients with atrial septal defect – the novel diagnostic indicator (RCD code: IV-2B.1)

Komar¹,

Podolec

Gancarczyk³

et al. 2015

Journal of Rare Cardiovascular Diseases

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Background: The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for ASD closure. Methods: 21 patients (11 F, 10 M), mean age 40.2 ± 11.9 years with pulmonary artery hypertension were enrolled for an attempt at ASD closure. A group of 19 healthy volunteers, (12 F, 7 M) mean age 39.2 ± 9.15 served as controls. All ASD patients underwent: clinical and echocardiographic study and cardiopulmonary exercise test. ET-1 levels were measured before and after closure. Whole blood was collected from femoral artery and vein and from pulmonary artery during cardiac catheterization. Results: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p<0.0001). The ASD subjects with highest ET-1 level presented the larger area of right ventricle and right atrium and higher pulmonary artery systolic pressure(p<0.05). The ASD subjects with lower ET-1 level demonstrated longer time of exercise and higher peak oxygen consumption (p<0.05). There was a decrease of ET-1 at peripheral artery (5.549 ± 5.32 vs. 1.92 ± 7.2; p<0.001) and at peripheral vein (4.012 ± 2.342 vs. 2.15 ± 1.15; p<0.001) within 48 hours after ASD closure, as compared to the baseline data. After 6 and 12 months farther drop in ET-1 level was observed. Conclusions: 1. The level of ET-1 in patients with ASD and pulmonary artery hypertension is elevated in compare to healthy subject. 2. The significant reduction of ET-1 level is observed after percutaneous closure of ASD. 3. Elevated level of ET-1 in patients with ASD is associated with right heart enlargement. 4. Measurements of ET-1 may be a supplemental diagnostic tool and may be helpful in establishing indications for defect closure. JRCD 2015; 2 (3): 77-81

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Improvement in Exercise Capacity in Asymptomatic and Mildly Symptomatic Adults After Atrial Septal Defect Percutaneous Closure

Abstract: Background-Controversy exists as to whether secundum atrial septal defects (ASDs) in asymptomatic or mildly symptomatic New York Heart Association (NYHA) class I or II adult patients should be closed.

Cited by 153 publications

References 20 publications

Pathophysiology of Congenital Heart Disease in the Adult

Pathophysiology of Congenital Heart Disease in the Adult

Why, When and How Should Atrial Septal Defects Be Closed in Adults

Plasma Endothelin-1 in patients with atrial septal defect – the novel diagnostic indicator (RCD code: IV-2B.1)

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