Improvement in Ethylene Glycol Bioconversion to Glycolic Acid by Gluconobacter oxydans Using Central Composite Experimental Design and Bioreactor Fed-Batch Strategies
Isabella Maria Tenório Soares Santos,
Evanildo F. de Souza,
Ricardo Gonzalo Ramirez Brenes
et al.
Abstract:This study focuses on optimizing the medium composition for cellular biomass production and bioconversion of ethylene glycol (EG) to glycolic acid (GA) using Gluconobacter oxydans CCT 0552. The improvement in cellular growth in the presence of yeast extract and peptone led to a 35.7% and 32.7% increase, respectively, compared to the medium with each of these carbon sources separately. Negligible growth was produced when (NH4)2SO4 and urea were used. Optimal bioconversion results were very similar for both the … Show more
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