Improvement in colistin‐induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin

Abstract

This study aimed to investigate the effect of chrysin on colistin‐induced reproductive toxicity. Twenty‐eight adult male Sprague‐Dawley rats were divided into four groups of seven rats each. Group I received physiological saline for 7 days. Group II received 50 mg/kg/day chrysin for 7 days. Group III received a total dose of 73 mg/kg colistin for 7 days. Group IV received 50 mg/kg/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin + colistin group compared with the colistin group. The highest caspase‐3 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin + colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. In conclusion, chrysin treatment can be beneficial against colistin‐induced reproductive toxicity.

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

“…Mercury is a proxidant that causes oxidative stress (El‐Desoky et al, ; Ibrahim et al, ; Khan et al, ). Pathological events in the reproductive system can be induced by oxidative stress (Aksu, Kandemir, Kucukler, & Mahamadu, ; Aksu et al, ). Oxidative stress occurs due to excessive increase in reactive oxygen species depending on the deterioration of oxidant–antioxidant balance in the body (Ak & Gulcin, ; Aksu et al, ; Bursal & Gülçin, ; Gulcin, ).…”

Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats

“…A rich composition of polyunsaturated fatty acids in the mammalian sperm cell membrane makes the cell sensitive to free radicals. There are many experimental studies reporting that increased ROS levels decrease sperm motility and quality and increase the rate of sperm death in the semen . Using antioxidant compounds may be a useful and important strategy for preventing male infertility caused by chemotherapy.…”

“…There are many experimental studies reporting that increased ROS levels decrease sperm motility and quality and increase the rate of sperm death in the semen. [15][16][17][18][19][20][21] Using antioxidant compounds may be a useful and important strategy for preventing male infertility caused by chemotherapy. Vendramini et al [9] reported that DOX treatment reduced sperm motility and concentration and increased the percentage of abnormal sperm, while amifostine treatment mitigated these parameters and reduced the damage to the seminiferous epithelium in testes of prepubertal rats.…”

Impact of chrysin on the molecular mechanisms underlying diabetic complications

“…Recently, it was indicated that chrysin administration ameliorated MDA level and antioxidant enzymes including superoxide dismutase, glutathione-S-transferase (GST), and catalase (CAT) activities in streptozotocin (STZ)-induced diabetic rats. The above-mentioned findings demonstrate the protective effect of chrysin against type 2 diabetic (Aksu, Kandemir, Küçükler, & Mahamadu, 2018). This study was designed to investigate the therapeutic effect of chrysin in diabetes complications and to find out the possible mechanisms by which chrysin provides this protection.…”