Improvement in blood lipid levels by dietary sn-1,3-diacylglycerol in young women with variants of lipid transporters 54T-FABP2 and -493g-MTP

Yanagisawa, Yoshiko; Kawabata, Takeshi; Tanaka, Osamu; Kawakami, Masanobu; Hasegawa, Kyoko; Kagawa, Yasuo

doi:10.1016/s0006-291x(03)00220-1

Cited by 15 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar discrepancies were also observed in various clinical studies, where some studies confirmed that DAG intake was able to decrease serum TAG levels Tada et al 2001;Yamamoto et al 2001Yamamoto et al , 2005Yanagisawa et al 2003), while others reported otherwise Meguro et al 2001;Maki et al 2002;Kamphuis et al 2003). However, DAG intake was shown to be beneficial in reducing serum TAG levels in young women with hyperlipidemia-prone variants of fatty acidbinding protein 2 and MTP (Yanagisawa et al 2003) and in type 2 diabetic patients (Yamamoto et al 2001).…”

Section: Potential Health Benefitssupporting

confidence: 69%

“…Reductions in serum TAG levels were observed in some studies (Hara et al 1993;Murata et al 1994;Taguchi et al 2000;Tada et al 2001;Yamamoto et al 2001Yamamoto et al , 2005Kondo et al 2003;Yanagisawa et al 2003), while in others, there was no change in serum TAG levels Meguro et al 2001;Soni et al 2001;Maki et al 2002;Kamphuis et al 2003;Sugimoto et al 2003a, b). Hara et al (1993) investigated on the effect of feeding diets containing 10% DAG oil to rats and concluded that DAG has an ability to reduce serum TAG levels.…”

Section: Potential Health Benefitsmentioning

confidence: 96%

“…The ingestion of DAG oil has been shown to reduce body fat accumulation Murase et al 2001Murase et al , 2002aMaki et al 2002;Meng et al 2004) and lower serum TAG levels (Hara et al 1993;Murata et al 1994;Taguchi et al 2000;Tada et al 2001;Yamamoto et al 2001;Kondo et al 2003;Yanagisawa et al 2003;Yamamoto et al 2005). Murase et al (2001) reported a 70% reduction in body weight of mice after 5 months on a diet containing 30% DAG oil.…”

Section: Potential Health Benefitsmentioning

confidence: 99%

“…However, DAG intake was shown to be beneficial in reducing serum TAG levels in young women with hyperlipidemia-prone variants of fatty acidbinding protein 2 and MTP (Yanagisawa et al 2003) and in type 2 diabetic patients (Yamamoto et al 2001). Additionally, the consumption of DAG oil also reduces glycosylated hemoglobin (HbAlc) concentrations in these diabetic patients (Yamamoto et al 2001).…”

Section: Potential Health Benefitsmentioning

confidence: 99%

See 3 more Smart Citations

Diacylglycerol Oil—Properties, Processes and Products: A Review

Tan

Long

et al. 2008

Food Bioprocess Technol

157

View full text Add to dashboard Cite

Diacylglycerol (DAG) oil has beneficial effects on obesity and weight-related disorders. A survey of literature has shown the effects of DAG on the reduction in the accumulation of body fat in both animals and humans. The physiological effect of DAG is believed to be attributed to its metabolic pathway, which is different from triacylglycerol (TAG) metabolism. Physicochemical properties, such as melting and smoke points and polymorphic forms, of DAG are also distinct from TAG. Various patented processes for DAG oil production from several reaction routes are discussed. A review of patent literature of commercial products based on DAG oils and fats is also provided.

show abstract

Section: Potential Health Benefitssupporting

confidence: 69%

Section: Potential Health Benefitsmentioning

confidence: 96%

Section: Potential Health Benefitsmentioning

confidence: 99%

Section: Potential Health Benefitsmentioning

confidence: 99%

See 2 more Smart Citations

Diacylglycerol Oil—Properties, Processes and Products: A Review

Tan

Long

et al. 2008

Food Bioprocess Technol

157

View full text Add to dashboard Cite

show abstract

“…We observed that the lower body weight associated with DAG oil feeding was also associated with lower total body fat as well as fat in trunk, android, and gynoid areas, consistent with previous findings (31)(32)(33)(34)(35). Contradictory data have shown that DAG oil exerted no effect on body weight and composition (7,36).…”

Section: Discussionsupporting

confidence: 91%

Diacylglycerol Oil Reduces Body Fat but Does Not Alter Energy or Lipid Metabolism in Overweight, Hypertriglyceridemic Women

Yuan

Ramprasath

Harding

et al. 2010

The Journal of Nutrition

View full text Add to dashboard Cite

Diacylglycerol (DAG) may undergo differential metabolism compared with triacylglycerol (TAG) in humans, possibly resulting in decreased serum TAG concentration and TAG synthesis and increased energy expenditure (EE), thus reducing fat accumulation. Our objective was to examine the efficacy of DAG oil (Enova oil) consumption on serum lipid profiles, hepatic lipogenesis, EE, and body weight and composition compared with a control oil-blend composed of sunflower, safflower, and rapeseed oils at a 1:1:1 ratio. Twenty-six overweight (78.3 +/- 3.6 kg body weight and BMI 30.0 +/- 0.7 kg/m(2)) mildly hypertriglyceridemic (1.81 +/- 0.66 mmol/L) women underwent 2 treatment phases of 28 d separated by a 4-wk washout period using a randomized crossover design. They consumed 40 g/d of either DAG or control oil during treatment phases. The baseline, EE, fat oxidation, body composition, and lipid profiles did not differ between the DAG and control oil intervention periods. Relative to control oil, DAG oil did not alter endpoint postprandial EE, fat oxidation, serum lipid profiles, or hepatic lipogenesis. However, DAG oil consumption reduced (P < 0.05) accumulation of body fat within trunk, android, and gynoid regions at the endpoint compared with control oil, although neither DAG nor control oil altered any of these variables during the 4-wk intervention period compared with their respective baseline levels. We conclude that although DAG oil is not effective in lowing serum lipids over a 4-wk intervention, it may be useful for reducing adiposity.

show abstract

Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile

et al. 2006

View full text Add to dashboard Cite

The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. A sample of 96 urban Aymara and 111 urban Mapuche subjects aged 20-80 years were recruited for this cross-sectional study. Glucose, insulin and lipid profile were measured in fasting plasma samples. Insulin resistance was estimated through the HOMA-IR model. FABP2 Ala54Thr genotypes were determined by PCR followed by RFLP analysis. The allele frequency of Thr54 variant was estimated as 18.2% in Aymara subjects, which is one of the lowest reported to date. The corresponding frequency in Mapuche subjects was 31.9% (p<0.002). Regarding genotype-phenotype associations, no significant differences were found in any of the anthropometric or metabolic variables according to Ala54Thr genotypes. After adjustment by BMI and metabolic variables through a logistic regression analysis, the association of the FABP2 polymorphism with ethnic group persisted (Mapuche group: OR=2.37, 95% CI 1.319-4.277, p=0.004) It is unlikely that Ala54Thr polymorphism of the FABP2 gene plays a relevant role in obesity and insulin resistance in Chilean ethnic groups.

show abstract

Improvement in blood lipid levels by dietary sn-1,3-diacylglycerol in young women with variants of lipid transporters 54T-FABP2 and -493g-MTP

Cited by 15 publications

References 27 publications

Diacylglycerol Oil—Properties, Processes and Products: A Review

Diacylglycerol Oil—Properties, Processes and Products: A Review

Diacylglycerol Oil Reduces Body Fat but Does Not Alter Energy or Lipid Metabolism in Overweight, Hypertriglyceridemic Women

Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile

Contact Info

Product

Resources

About